Human Immunity and Susceptibility to Influenza A(H3) Viruses of Avian, Equine, and Swine Origin

被引：4
|
作者：
Vandoorn, Elien [1 ]
Stadejek, Wojciech [1 ]
Leroux-Roels, Isabel [2 ]
Leroux-Roels, Geert [2 ]
Parys, Anna [1 ]
Van Reeth, Kristien [1 ,3 ]
机构：
[1] Univ Ghent, Merelbeke, Belgium
[2] Ghent Univ Hosp, Ghent, Belgium
[3] Univ Ghent, Fac Vet Med, Lab Virol, Salisburylaan 133, B-9820 Merelbeke, Belgium
来源：
EMERGING INFECTIOUS DISEASES | 2023年 / 29卷 / 01期
关键词：
A VIRUSES; SEROLOGICAL EVIDENCE; GENETIC EVOLUTION; HUMAN INFECTION; DOMESTIC DUCKS; NORTH-AMERICAN; WILD BIRDS; H3N2; PIGS; REPLICATION;
D O I：
10.3201/eid2901.220943
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Influenza A viruses (IAVs) of subtype H3 that infect hu-mans are antigenically divergent from those of birds, horses, and swine. Human immunity against these vi-ruses might be limited, implying potential pandemic risk. To determine human risk, we selected 4 avian, 1 equine, and 3 swine IAVs representing major H3 lineages. We tested serum collected during 2017-2018 from 286 per-sons in Belgium for hemagglutination inhibiting antibod-ies and virus neutralizing antibodies against those ani-mal-origin IAVs and tested replication in human airway epithelia. Seroprevalence rates for circulating IAVs from swine in North America were >51%, swine in Europe 7%-37%, and birds and equids <= 12%. Replication was efficient for cluster IAVs from swine in North America and IAVs from swine in Europe, intermediate for IAVs from horses and poultry, and absent for IAVs from wild birds and a novel human-like swine IAV in North Ameri-ca. Public health risk may be highest for swine H3 IAVs.
引用
收藏
页码：98 / 109
页数：12
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