ZIP transporters-regulated Zn2+ homeostasis: A novel determinant of human diseases

被引：2
|
作者：
Liu, Huimei [1 ]
Li, Lanfang [1 ,2 ,3 ]
Lu, Ruirui [2 ,3 ]
机构：
[1] Univ South China, Hengyang Med Sch, Dept Pharmacol, Hengyang, Peoples R China
[2] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang, Peoples R China
[3] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Peoples R China
来源：
JOURNAL OF CELLULAR PHYSIOLOGY | 2024年 / 239卷 / 05期
基金：
中国国家自然科学基金;
关键词：
cancers; cardiovascular diseases; neurological diseases; zinc; ZIP transporters; EPITHELIAL-MESENCHYMAL TRANSITION; ZIP14-MEDIATED ZINC TRANSPORT; COLORECTAL-CANCER; GROWTH; EXPRESSION; KNOCKDOWN; FIBROSIS; TUMORIGENESIS; LOCALIZATION; CONTRIBUTES;
D O I：
10.1002/jcp.31223
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
As an essential trace element for organisms, zinc participates in various physiological processes, such as RNA transcription, DNA replication, cell proliferation, and cell differentiation. The destruction of zinc homeostasis is associated with various diseases. Zinc homeostasis is controlled by the cooperative action of zinc transporter proteins that are responsible for the influx and efflux of zinc. Zinc transporter proteins are mainly categorized into two families: Zrt/Irt-like protein (SLC39A/ZIP) family and zinc transporter (SLC30A/ZNT) family. ZIP transporters contain 14 members, namely ZIP1-14, which can be further divided into four subfamilies. Currently, ZIP transporters-regulated zinc homeostasis is one of the research hotspots. Cumulative evidence suggests that ZIP transporters-regulated zinc homeostasis may cause physiological dysfunction and contribute to the onset and progression of diverse diseases, such as cancers, neurological diseases, and cardiovascular diseases. In this review, we initially discuss the structure and distribution of ZIP transporters. Furthermore, we comprehensively review the latest research progress of ZIP transporters-regulated zinc homeostasis in diseases, providing a new perspective into new therapeutic targets for treating related diseases.
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收藏
页数：24
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