Clinical considerations in Parkinson's disease cell therapy

被引：6

作者：

Xue, Jun ^{[1
,2
]}

Wu, Yifan ^{[1
,2
]}

Bao, Yuting ^{[1
,2
]}

Zhao, Minglai ^{[1
,2
]}

Li, Fangzhou ^{[1
,2
]}

Sun, Jing ^{[3
]}

Sun, Yimin ^{[4
]}

Wang, Jian ^{[4
]}

Chen, Liang ^{[1
,2
]}

Mao, Ying ^{[1
,2
]}

Schweitzer, Jeffrey S. ^{[5
]}

Song, Bin ^{[1
,2
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China

[2] Fudan Univ, Shanghai Clin Med Ctr Neurosurg, Neurosurg Inst,Shanghai Key Lab Brain Funct & Res, Natl Ctr Neurol Disorders, Shanghai 200040, Peoples R China

[3] Fudan Univ, MOE Frontiers Ctr Brain Sci, Inst Translat Brain Res, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China

[4] Fudan Univ, Huashan Hosp, Shanghai Med Coll, Inst Neurol,Natl Clin Res Ctr Aging & Med, Shanghai 200032, Peoples R China

[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurosurg, Boston, MA 02114 USA

来源：

AGEING RESEARCH REVIEWS | 2023年 / 83卷

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

Parkinson?s disease; Cell therapy; Dopamine cells; Transplantation; Clinical trial; FETAL DOPAMINE NEURONS; IMPROVES XENOGRAFT SURVIVAL; GRAFT-INDUCED DYSKINESIAS; RIGHT CAUDATE-NUCLEUS; LONG-TERM SURVIVAL; MESENCEPHALIC TISSUE; PRIMATE MODEL; NIGRAL TRANSPLANTATION; GENE-THERAPY; NEURAL PROGENITORS;

D O I：

10.1016/j.arr.2022.101792

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell replacement therapy is an area of increasing interest for treating Parkinson's disease (PD). However, to become a clinically practical option for PD patients, it must first overcome significant barriers, including establishment of safe and standardized surgical procedures, determination of appropriate perioperative medication regimens, demonstration of long-term graft survival and incorporation, and standardized, clinically meaningful follow-up measures. In this review, we will describe the current status of cell therapy for PD with special attention to these critical requirements, to define guideposts on the road to bring the benefit of this therapy to the Parkinson's clinic.

引用

页数：20

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