B(C6F5)3-mediated direct intramolecular C7-alkenylation of N-propargylindoles

被引：2
|
作者：
Cui, Jie [1 ]
Wang, Tongdao [1 ]
机构：
[1] Dalian Univ Technol, Sch Chem, Dalian 116024, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 68期
基金：
中国国家自然科学基金;
关键词：
C-H; INDOLE ALKALOIDS; C7-FUNCTIONALIZATION; FUNCTIONALIZATION; REARRANGEMENT; ALKYLATION; ACTIVATION; REACTIVITY; ARYLATION; AMINES;
D O I：
10.1039/d3cc02599c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
B(C6F5)(3)-mediated direct C7-alkenylation of N-propargylindoles without directing groups was developed. This reaction proceeds via the & pi;-activation of the alkynyl group with B(C6F5)(3)/Friedel-Crafts alkenylation/proton transfer reaction sequence. Interestingly, C7-alkenylation products could further convert into the fused indoles by deprotonation and finally polyaromatic N-heterocycles by the hydride abstraction.
引用
收藏
页码：10279 / 10282
页数：4
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