Targeting stromal metabolism in pancreatic ductal adenocarcinoma

被引：0
|
作者：
Yin, Miao [1 ,2 ,3 ]
Lei, Qun-Ying [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, State Key Lab Med Neurobiol, Inst Biomed Sci,Canc Inst,Sch Basic Med Sci,Key La, Shanghai, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
[4] New Cornerstone Sci Lab, Shanghai, Peoples R China
来源：
NATURE CELL BIOLOGY | 2024年 / 26卷 / 04期
关键词：
FIBROBLASTS;
D O I：
10.1038/s41556-023-01330-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The tumour microenvironment produces nutrients that propel cancer development. New work finds that pancreatic ductal adenocarcinoma cells use one such nutrient, acetate, to alter protein acetylation, rerouting polyamine metabolism and promoting cell growth under acidosis-a finding with potential implications for treating this cancer.
引用
收藏
页码：514 / 515
页数：2
相关论文
共 50 条
  • [41] Targeting cancer cell metabolism in pancreatic adenocarcinoma
    Cohen, Romain
    Neuzillet, Cindy
    Tijeras-Raballand, Annemilai
    Faivre, Sandrine
    de Gramont, Armand
    Raymond, Eric
    ONCOTARGET, 2015, 6 (19) : 16832 - 16847
  • [42] A novel hedgehog signaling inhibitor for targeting pancreatic ductal adenocarcinoma
    Khire, Atul
    Zhong, Yi
    Rajanala, Kalpana
    Iacobuzio-Donahue, Christine
    Resh, Marilyn D.
    CANCER RESEARCH, 2019, 79 (13)
  • [43] The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives
    Wu, Yang
    Zhang, Chun
    Jiang, Kuirong
    Werner, Jens
    Bazhin, Alexandr V.
    D'Haese, Jan G.
    FRONTIERS IN ONCOLOGY, 2021, 10
  • [44] Targeting LDLR-overexpressing glioblastoma and pancreatic ductal adenocarcinoma
    Tworowska, Izabela
    Flores, Leo, II
    Qu, Xuewei
    Malicet, Cedric
    Lecorche, Pascaline
    Temsamani, Jamal
    Delpassand, Ebrahim
    NUCLEAR MEDICINE AND BIOLOGY, 2022, 108 : S217 - S218
  • [45] A rat model of pancreatic ductal adenocarcinoma: Targeting chemical carcinogens
    Rivera, JA
    GraemeCook, F
    Werner, J
    Zgraggen, K
    Rustgi, AK
    Rattner, DW
    Warshaw, AL
    FernandezdelCastillo, C
    SURGERY, 1997, 122 (01) : 82 - 90
  • [46] Peptides as a targeting strategy to eradicate Pancreatic Ductal Adenocarcinoma (PDAC)
    Parrasia, Sofia
    Rossa, Andrea
    Bachmann, Magdalena
    Corbo, Vincenzo
    Mattarei, Andrea
    Ruzza, Paolo
    Biasutto, Lucia
    Szabo, Ildiko
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2024, 1870 (08): : 10 - 10
  • [47] Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma
    Skorupan, Nebojsa
    Dominguez, Mayrel Palestino
    Ricci, Samuel L.
    Alewine, Christine
    CANCERS, 2022, 14 (17)
  • [48] Targeting KRAS in Pancreatic Ductal Adenocarcinoma: The Long Road to Cure
    de Jesus, Victor Hugo Fonseca
    Mathias-Machado, Maria Cecilia
    de Farias, Joao Paulo Fogacci
    Aruquipa, Marcelo Porfirio Sunagua
    Jacome, Alexandre A.
    Peixoto, Renata D'Alpino
    CANCERS, 2023, 15 (20)
  • [49] Therapeutic targeting of lipid oxidation and apoptosis in pancreatic ductal adenocarcinoma
    Hartman, Sarah J.
    Nadales, Nathalie
    Bagby, Stacey M.
    Yacob, Betelehem W.
    Gittleman, Brian L.
    Estrada-Bernal, Adriana
    Le, Anh T.
    Lieu, Christopher H.
    Davis, S. Lindsey
    Leal, Alexis D.
    Diamond, Jennifer R.
    Messersmith, Wells A.
    Schlaepfer, Isabel R.
    Pitts, Todd M.
    CANCER RESEARCH, 2020, 80 (16)
  • [50] Targeting acidosis to improve immunotherapy in a pancreatic ductal adenocarcinoma model
    Perassi, B. Victorasso Jardim
    Abrahams, D.
    Irrera, P.
    Whelan, C.
    Beatty, M.
    Byrne, S.
    Longo, D.
    Gaspar, K.
    Pilon-Thomas, S.
    Hashim, A. Ibrahim
    Bohler, C.
    Gillies, R.
    EUROPEAN JOURNAL OF CANCER, 2022, 174 : S90 - S91
12345