Two new terpenoids from the branches and leaves of Rhododendron dauricum L. with neuroprotective activity

被引:0
|
作者
Wu, Ying [1 ]
Yu, Xin [2 ]
Gao, Hongying [1 ]
Gao, Peipei [1 ]
Gao, Zhihong [3 ]
机构
[1] Cangzhou Cent Hosp, Pediat Endocrine Dept, Cangzhou, Peoples R China
[2] Blood Donat Serv, Dept Cangzhou Cent Blood Stn, Cangzhou, Peoples R China
[3] Beijing Univ Chinese Med, Oriental Coll, Huanghua, Peoples R China
关键词
Rhododendron dauricum L; terpenoids; Neuroprotective activity; X-ray analysis; SESQUITERPENES; TRITERPENOIDS; BARK;
D O I
10.1080/14786419.2024.2308000
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Two new terpenoids were isolated from the branches and leaves of Rhododendron dauricum L., named as rhodayritions A (1) and B (2), together with five known compounds which were identified litseachromolaevane A (3), 11-alpha H-dihydrodehydrocostus lactone (4), (+)-9 beta-hydroxyeudesma-4,11(13)-dien-12-al (5), macrostachyoside B (6) and aglaiabbreviatin E (7), respectively. The structures of isolated compounds were determined by UV, HR-ESI-MS, NMR analysis and X-Ray. Their neuroprotective activity was studied on serum deprivation-induced PC12 cells by the MTT method, compounds 1, 6, and 7 exhibited significant neuroprotective activity at 20 mu M.
引用
收藏
页数:6
相关论文
共 50 条
  • [41] TDZ-induced two-step regeneration and histological analysis of morphogenesis from pedicel tissue of Rhododendron dauricum L., a semi-evergreen species
    Zaytseva, Yulianna G.
    Novikova, Tatyana, I
    IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT, 2022, 58 (06) : 911 - 920
  • [42] Chemical composition of leaves and branches of Cedrela odorata L. from two forest plantations as a source of lignocellulosic feedstock
    Rosales-Castro, Martha
    Amador Honorato-Salazar, J.
    Berenice Santos-Garcia, Ariana
    Elena Perez-Lopez, Ma.
    Colotl-Hernandez, Gertrudis
    Sanchez-Monsalvo, Vicente
    MADERA Y BOSQUES, 2016, 22 (02) : 131 - 146
  • [43] ACUTUMININE A NEW ALKOLOID FROM LEAVES OF MENISPERMUM DAURICUM DC
    OKAMOTO, Y
    YUGE, E
    NAGAI, Y
    KATSUTA, R
    KISHIMOTO, A
    KOBAYASHI, Y
    KIKUCHI, T
    TOMITA, M
    TETRAHEDRON LETTERS, 1969, (24) : 1933 - +
  • [44] Two New Lanostane Triterpenoids from the Branches and Leaves of Polyalthia oblique
    Wang, Liu-Kai
    Zheng, Cai-Juan
    Li, Xiao-Bao
    Chen, Guang-Ying
    Han, Chang-Ri
    Chen, Wen-Hao
    Song, Xiao-Ping
    MOLECULES, 2014, 19 (06) : 7621 - 7628
  • [45] Two new natural methoxyflavonoids from leaves of Murraya paniculata(L.) Jack
    Hua Yao
    Yong-ri Jin
    Jing Shan
    Xiao-zhong Wang
    Mu-chun Zhang
    Xu-wen Li
    Chemical Research in Chinese Universities, 2013, 29 : 884 - 887
  • [46] Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L.
    Truong Van Nguyen Thien
    Vi Ha Thi Huynh
    Loan Kieu Thi Vo
    Nhan Trong Tran
    Thuat My Luong
    Tho Huu Le
    Toan Phan Duc
    Quang Ton That
    PHYTOCHEMISTRY LETTERS, 2017, 20 : 119 - 122
  • [47] Two new natural methoxyflavonoids from leaves of Murraya paniculata(L.) Jack
    Yao Hua
    Jin Yong-ri
    Shan Jing
    Wang Xiao-zhong
    Zhang Mu-chun
    Li Xu-wen
    CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2013, 29 (05) : 884 - 887
  • [48] The neuroprotective activity of a proanthocyanidin enriched Ginkgo biloba L. leaves extract in vitro and in vivo
    Kuchta, K.
    Qiao, H. X.
    Huang, H. B.
    Fang, L.
    Chen, Y.
    Wang, R. W.
    PLANTA MEDICA, 2016, 82
  • [49] Pharmacological Activity and Mechanisms of Action of Terpenoids from Laurus nobilis L.
    Kamdem, Boniface Pone
    Kamto, Eutrophe Le Doux
    Soh, Desire
    Pegnyemb, Dieudonne Emmanuel
    Zingue, Stephane
    Paumo, Hugues Kamdem
    Katata-Seru, Lebogang Maureen
    Abou, Aboubakar
    Rosinah, Montsho Maiyane
    Mbah, James Ajeck
    Boyom, Fabrice Fekam
    NATURAL PRODUCTS JOURNAL, 2023, 13 (07): : 2 - 19
  • [50] Hyperipersions A-C, three new acylphloroglucinols from the branches and leaves of Hypericum perforatum L. with antiangiogenic activities
    Zhang, Hao
    Wang, Kunling
    Chen, Fan
    NATURAL PRODUCT RESEARCH, 2024, 38 (23) : 4134 - 4140