Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Transplant-ineligible Patients with Newly Diagnosed Multiple Myeloma (NDMM): Updated Analysis of the Phase 3 MAIA Study

被引:0
|
作者
Kumar, S. K. [1 ]
Moreau, P. [2 ]
Bahlis, N. [3 ]
Facon, T. [4 ]
Plesner, T. [5 ,6 ]
Orlowski, R. Z. [7 ]
Basu, S. [8 ,9 ]
Nahi, H. [10 ]
Hulin, C. [11 ]
Quach, H. [12 ]
Goldschmidt, H. [13 ,14 ]
O'Dwyer, M. [15 ]
Perrot, A. [16 ]
Venner, C. P. [17 ,18 ]
Weisel, K. [19 ]
Raje, N. [20 ]
Tiab, M. [21 ]
Macro, M. [22 ]
Frenzel, L. [23 ]
Leleu, X. [24 ]
Wang, G. [25 ]
Krevvata, M. [25 ]
Carson, R. [25 ]
Borgsten, F. [26 ]
Usmani, S. Z. [27 ]
机构
[1] Mayo Clin Rochester, Dept Hematol, Rochester, MN USA
[2] Univ Hosp Hotel Dieu, Hematol Dept, Nantes, France
[3] Univ Calgary, Arnie Charbonneau Canc Res Inst, Calgary, AB, Canada
[4] Univ Lille, CHU Lille, Serv Malad Sang, Lille, France
[5] Vejle Hosp, Vejle, Denmark
[6] Univ Southern Denmark, Vejle, Denmark
[7] Univ Texas MD Anderson Canc Ctr, Dept Lymphoma & Myeloma, Houston, TX 77030 USA
[8] Royal Wolverhampton NHS Trust, Wolverhampton, England
[9] Wolverhampton Univ, CRN West Midlands, NIHR, Wolverhampton, England
[10] Karolinska Inst, Karolinska Univ Hosp Huddinge, Div Hematol, Dept Med, Stockholm, Sweden
[11] Univ Hosp, Dept Hematol, Hop Haut Leveque, Pessac, France
[12] Univ Melbourne, St Vincents Hosp, Melbourne, Vic, Australia
[13] Univ Hosp Heidelberg, Internal Med 5, Heidelberg, Germany
[14] Natl Ctr Tumor Dis NCT, Heidelberg, Germany
[15] NUI, Dept Med Haematol, Galway, Ireland
[16] Univ Toulouse, CHU Toulouse, Serv Hematol, IUCT O,UPS, Toulouse, France
[17] Univ Alberta, Cross Canc Inst, Dept Med Oncol, Edmonton, AB, Canada
[18] BC Canc, Vancouver Ctr Grp, Vancouver, BC, Canada
[19] Univ Med Ctr Hamburg Eppendorf, Sect Pneumol, Dept Oncol Hematol & Bone Marrow Transplantat, Hamburg, Germany
[20] Massachusetts Gen Hosp, Canc Ctr, Ctr Multiple Myeloma, Boston, MA 02114 USA
[21] CHD Vendee, La Roche Sur Yon, France
[22] Ctr Hosp Univ CHU Caen, Caen, France
[23] Hop Necker Enfants Malad, Paris, France
[24] CHU Poitiers, Hop Miletrie, Poitiers, France
[25] Janssen Res & Dev LLC, Spring House, PA USA
[26] Janssen Res & Dev LLC, Raritan, NJ USA
[27] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P342
引用
收藏
页码:183 / 184
页数:2
相关论文
共 50 条
  • [41] UPDATED EFFICACY AND SAFETY ANALYSIS OF DARATUMUMAB, LENALIDOMIDE, AND DEXAMETHASONE (DRd) VERSUS LENALIDOMIDE AND DEXAMETHASONE (Rd) FOR RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM; POLLUX)
    Moreau, P.
    White, D.
    Benboubker, L.
    Cook, G.
    Leiba, M.
    Morton, J.
    Ho, P. J.
    Kim, K.
    Takezako, N.
    Trivedi, S.
    Wu, K.
    Casneuf, T.
    Chiu, C.
    Schecter, J. M.
    Dimopoulos, M. A.
    HAEMATOLOGICA, 2018, 103 : 31 - 31
  • [42] Daratumumab, Lenalidomide, and Dexamethasone (DRd) Versus Lenalidomide and Dexamethasone (Rd) in Relapsed or Refractory Multiple Myeloma (RRMM): Updated Efficacy and Safety Analysis of Pollux
    Dimopoulos, Meletios A.
    White, Darrell J.
    Benboubker, Lofti
    Cook, Gordon
    Leiba, Merav
    Morton, James
    Ho, P. Joy
    Kim, Kihyun
    Takezako, Naoki
    Trivedi, Sonali
    Wu, Kaida
    Casneuf, Tineke
    Chiu, Christopher
    Schecter, Jordan
    Moreau, Philippe
    BLOOD, 2017, 130
  • [43] Phase III (IMROZ) study design: Isatuximab plus bortezomib (V), lenalidomide (R), and dexamethasone (d) vs VRd in transplant-ineligible patients (pts) with newly diagnosed multiple myeloma (NDMM).
    Orlowski, Robert Z.
    Goldschmidt, Hartmut
    Cavo, Michele
    Martin, Thomas G.
    Paux, Gautier
    Oprea, Corina
    Facon, Thierry
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [44] Sustained Improvement in HealthRelated Quality of Life in TransplantIneligible Patients with Newly Diagnosed Multiple Myeloma Treated with Daratumumab, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone: Update of the Phase 3 MAIA Trial
    Perrot, Aurore
    Facon, Thierry
    Kumar, Shaji
    Plesner, Torben
    Orlowski, Robert Z.
    Moreau, Philippe
    Bahlis, Nizar J.
    Basu, Supratik
    Nahi, Hareth
    Hulin, Cyrille
    Quach, Hang
    Goldschmidt, Hartmut
    O'Dwyer, Michael E.
    Venner, Chris P.
    Weisel, Katja
    Mace, Joseph R.
    Raje, Noopur S.
    Tiab, Mourad
    Macro, Magaret
    Frenzel, Laurent
    Leleu, Xavier
    Liu, Kevin
    Fastenau, John
    Gries, Katharine S.
    Ho, Kai Fai
    Mistry, Pankaj
    Tromp, Brenda
    Delioukina, Maria
    Vermeulen, Jessica
    Usmani, Saad Z.
    BLOOD, 2021, 138
  • [45] Updates from a phase Ib study of isatuximab (Isa), bortezomib (V) and dexamethasone (D) plus cyclophosphamide (C) or lenalidomide (R) in transplant-ineligible, newly diagnosed multiple myeloma (NDMM).
    Ocio, Enrique M.
    Rodriguez Otero, Paula
    Bringhen, Sara
    Oliva, Stefania
    Nogai, Axel
    Attal, Michel
    Moreau, Philippe
    Martinez-Lopez, Joaquin
    Le Roux, Nadia
    Mace, Sandrine
    Rouchon, Marie-Claude
    Wang, Qiuyan
    Mateos, Maria-Victoria
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [46] A phase 2 study of modified lenalidomide, bortezomib and dexamethasone in transplant-ineligible multiple myeloma
    O'Donnell, Elizabeth K.
    Laubach, Jacob P.
    Yee, Andrew J.
    Chen, Tianqi
    Huff, Carol Ann
    Basile, Frank G.
    Wade, Philip M.
    Paba-Prada, Claudia E.
    Ghobrial, Irene M.
    Schlossman, Robert L.
    Burke, Jill N.
    Harrington, Cynthia C.
    Lively, Kathleen J.
    Lyons, Hannah F.
    Munshi, Nikhil C.
    Anderson, Kenneth C.
    Trippa, Lorenzo
    Richardson, Paul G.
    Raje, Noopur S.
    BRITISH JOURNAL OF HAEMATOLOGY, 2018, 182 (02) : 222 - 230
  • [47] Daratumumab (DARA) plus lenalidomide/bortezomib/dexamethasone (RVd) in Black patients with transplant-eligible newly diagnosed multiple myeloma (NDMM): an updated subgroup analysis of GRIFFIN
    Nooka, Ajay
    Kaufman, Jonathan
    Rodriguez, Cesar
    Jakubowiak, Andrzej
    Efebera, Yvonne
    Reeves, Brandi
    Wildes, Tanya
    Holstein, Sarah
    Anderson, Larry
    Badros, Ashraf
    Shune, Leyla
    Chari, Ajai
    Pei, Huiling
    Cortoos, Annelore
    Patel, Sharmila
    Lin, Thomas
    Usmani, Saad
    Richardson, Paul
    Voorhees, Peter
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2022, 22 : S155 - S156
  • [48] Ixazomib or Lenalidomide combined with cyclophosphamide and dexamethasone in the treatment of elderly transplant-ineligible newly diagnosed multiple myeloma
    Wang, Yan
    Liu, Yuan-Fang
    Jin, Shi-Wei
    Tao, Yi
    Zhang, Wei-Ping
    Chen, Jian-Lin
    Jiang, Song-Fu
    Mi, Jian-Qing
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [49] A comparison of lenalidomide/dexamethasone (RD) versus cyclophosphamide/lenalidomide/dexamethasone (CRD) versus cyclophosphamide/bortezomib/dexamethasone (CyborD) in newly diagnosed multiple myeloma (MM)
    Khan, M. L.
    Reeder, C. B.
    Kumar, S.
    Lacy, M.
    Reece, D. E.
    Laumann, K. M.
    Mikhael, J.
    Fonseca, R.
    Rajkumar, V.
    Stewart, A. K.
    JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
  • [50] A Phase II Study of Modified Lenalidomide, Bortezomib, and Dexamethasone (RVD-lite) for Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma
    O'Donnell, Elizabeth K.
    Laubach, Jacob P.
    Yee, Andrew J.
    Huff, Carol A.
    Basile, Frank G.
    Wade, Philip M., Jr.
    Paba-Prada, Claudia E.
    Ghobrial, Irene M.
    Schlossman, Robert L.
    Couture, Nicole R.
    Doherty, Lauren
    Lyons, Hannah
    English, Caroline
    Munshi, Nikhil C.
    Anderson, Kenneth C.
    Richardson, Paul C.
    Raje, Noopur S.
    BLOOD, 2015, 126 (23)