Prolongation of spinal duration by escalating doses of intrathecal epinephrine in lower limb arthroplasty

被引:1
|
作者
Wolla, Christopher D. [1 ]
Epperson, Tom, I [1 ]
Woltz, Erick M. [2 ]
Wolf, Bethany J. [3 ]
Bolin, Eric D. [1 ]
机构
[1] Med Univ South Carolina, Dept Anesthesiol & Perioperat Med, Charleston, SC 29425 USA
[2] Prisma Hlth, Dept Family Med, Greenville, SC 29605 USA
[3] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA
关键词
anesthesia adjuvants; epinephrine; intrathecal injections; spinal anesthesia; total hip arthroplasty; total knee arthroplasty; ANESTHESIA; BUPIVACAINE; LIDOCAINE; ANALGESIA; BLOCK; LABOR;
D O I
10.2217/pmt-2023-0068
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Aim: The optimal dose of low-dose intrathecal epinephrine in the absence of intrathecal opioids is unknown. Materials & methods: Prospective, randomized, double blind clinical trial of patients undergoing lower limb arthroplasties. The primary end point was spinal block duration measured via motor and sensory block duration. Results: 30 patients undergoing lower limb arthroplasty were randomized into one of six groups with varying intrathecal epinephrine doses 0-100 mcg. There was a direct linear effect between motor block duration and intrathecal epinephrine dose with higher doses being associated with longer block duration (p = 0.011). Mean motor block duration was 3.74 +/- 1.13, 3.36 +/- 0.47, 3.39 +/- 0.60, 4.06 +/- 0.98 and 5.20 +/- 1.41 h for the EPI0, EPI25, EPI50, EPI75 and EPI100 groups respectively. Conclusion: This study reveals that low-dose intrathecal epinephrine (75-100 mcg) in the absence of intrathecal opioids can be reliably used to prolong motor block duration in lower limb arthroplasty.Clinical Trial Registration: NCT02619409 (ClinicalTrials.gov) What is this summary about?Here, we summarize the results of the addition of a medicine called epinephrine to a type of anesthesia called spinal anesthesia which involves injection of medication into the fluid surrounding the spinal cord. The study was to determine the optimal amount of epinephrine needed to prolong the effect of spinal anesthesia for patients undergoing replacements of their hips and/or knees.What were the results?The study showed that the addition of low-dose epinephrine to spinal anesthesia prolongs the motor block - or inability to move the leg - in a linear fashion with higher doses of epinephrine associated with longer motor block. Our results did not show a significant difference in sensory block, or the inability to feel the leg.What do the results mean?The study shows that the addition of low-dose epinephrine to spinal anesthesia can reliably prolong the effect of the anesthesia which may be needed in more complicated hip or knee surgeries. A prospective, randomized clinical trial investigating escalating doses of low dose intrathecal epinephrine in lower limb arthroplasty found that 75-100 mcg of intrathecal epinephrine can reliably prolong spinal motor block duration.
引用
收藏
页码:647 / 654
页数:8
相关论文
共 42 条
  • [41] Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial
    Hewson, David W.
    Worcester, Frank
    Sprinks, James
    Smith, Murray D.
    Buchanan, Heather
    Breedon, Philip
    Hardman, Jonathan G.
    Bedforth, Nigel M.
    TRIALS, 2019, 20 (1)
  • [42] Anaesthetist-controlled versus patient-maintained effect-site targeted propofol sedation during elective primary lower-limb arthroplasty performed under spinal anaesthesia (ACCEPTS): study protocol for a parallel-group randomised comparison trial
    David W. Hewson
    Frank Worcester
    James Sprinks
    Murray D. Smith
    Heather Buchanan
    Philip Breedon
    Jonathan G. Hardman
    Nigel M. Bedforth
    Trials, 20