Combination cancer imaging and phototherapy mediated by membrane-wrapped nanoparticles

被引:2
|
作者
Aboeleneen, Sara B. [1 ]
Scully, Mackenzie A. [1 ]
Kramarenko, George C. [1 ]
Day, Emily S. [1 ,2 ,3 ]
机构
[1] Univ Delaware, Dept Biomed Engn, Newark, DE 19716 USA
[2] Univ Delaware, Dept Mat Sci & Engn, Newark, DE USA
[3] Helen F Graham Canc Ctr & Res Inst, Newark, DE USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Biomimicry; photothermal therapy; theranostic; multimodal imaging; nanomedicine; hyperthermia; BLOOD-CELL MEMBRANE; CAMOUFLAGED MELANIN NANOPARTICLES; COATED MAGNETIC NANOPARTICLES; THERAPY; DELIVERY; SIZE;
D O I
10.1080/02656736.2023.2272066
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cancer is a devastating health problem with inadequate treatment options. Many conventional treatments for solid-tumor cancers lack tumor specificity, which results in low efficacy and off-target damage to healthy tissues. Nanoparticle (NP)-mediated photothermal therapy (PTT) is a promising minimally invasive treatment for solid-tumor cancers that has entered clinical trials. Traditionally, NPs used for PTT are coated with passivating agents and/or targeting ligands, but alternative coatings are being explored to enhance tumor specific delivery. In particular, cell-derived membranes have emerged as promising coatings that improve the biointerfacing of photoactive NPs, which reduces their immune recognition, prolongs their systemic circulation and increases their tumor accumulation, allowing for more effective PTT. To maximize treatment success, membrane-wrapped nanoparticles (MWNPs) that enable dual tumor imaging and PTT are being explored. These multifunctional theranostic NPs can be used to enhance tumor detection and/or ensure a sufficient quantity of NPs that have arrived in the tumor prior to laser irradiation. This review summarizes the current state-of-the-art in engineering MWNPs for combination cancer imaging and PTT and discusses considerations for the path toward clinical translation.
引用
收藏
页数:16
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