Vascular calcification and cellular signaling pathways as potential therapeutic targets

被引：11

作者：

Kang, Jeong-Hun ^{[1
]}

Kawano, Takahito ^{[2
]}

Murata, Masaharu ^{[2
]}

Toita, Riki ^{[3
,4
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr Res Inst, 6-1 Shinmachi, Suita, Osaka 5648565, Japan

[2] Kyushu Univ, Ctr Adv Med Innovat, 3-1-1 Maidashi,Higashi Ku, Fukuoka 8128582, Japan

[3] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, 1-8-31 Midorigaoka, Ikeda, Osaka 5638577, Japan

[4] Osaka Univ, Adv Photon & Biosensing Open Innovat Lab, AIST, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan

来源：

LIFE SCIENCES | 2024年 / 336卷

关键词：

Cardiovascular disease; Heart; Vessel; Signaling pathway; Inhibitor; Mineralization; SMOOTH-MUSCLE-CELLS; CORONARY-ARTERY CALCIFICATION; ENDOPLASMIC-RETICULUM STRESS; IN-VITRO CALCIFICATION; PHOSPHATE-INDUCED CALCIFICATION; VALVULAR INTERSTITIAL-CELLS; HORMONE-RELATED PEPTIDE; MESENCHYMAL STEM-CELLS; PROTEIN-KINASE-A; OSTEOGENIC DIFFERENTIATION;

D O I：

10.1016/j.lfs.2023.122309

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Increased vascular calcification (VC) is observed in patients with cardiovascular diseases such as atherosclerosis, diabetes, and chronic kidney disease. VC is divided into three types according to its location: intimal, medial, and valvular. Various cellular signaling pathways are associated with VC, including the Wnt, mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, cyclic nucleotide-dependent protein kinase, protein kinase C, calcium/calmodulin-dependent kinase II, adenosine monophosphate-activated protein kinase/mammalian target of rapamycin, Ras homologous GTPase, apoptosis, Notch, and cytokine signaling pathways. In this review, we discuss the literature concerning the key cellular signaling pathways associated with VC and their role as potential therapeutic targets. Inhibitors to these pathways represent good candidates for use as potential therapeutic agents for the prevention and treatment of VC.

引用

页数：20

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