Sex differences in childhood cancer risk among children with major birth defects: a Nordic population-based nested case-control study

被引:3
|
作者
Daltveit, Dagrun Slettebo [1 ,2 ]
Klungsoyr, Kari [1 ,3 ]
Engeland, Anders [1 ,3 ]
Ekbom, Anders [4 ]
Gissler, Mika [5 ,6 ,7 ]
Glimelius, Ingrid [4 ,8 ]
Grotmol, Tom [9 ]
Madanat-Harjuoja, Laura [10 ,11 ]
Ording, Anne Gulbech [12 ,13 ]
Sorensen, Henrik Toft [12 ,13 ]
Troisi, Rebecca [14 ]
Bjorge, Tone [1 ,9 ]
机构
[1] Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway
[2] Haukeland Hosp, Surg Clin, Norwegian Qual Registry Cleft Lip & Palate, Bergen, Norway
[3] Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway
[4] Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden
[5] Finnish Inst Hlth & Welf, Dept Knowledge Brokers, Helsinki, Finland
[6] Acad Primary Hlth Care Ctr, Stockholm, Sweden
[7] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
[8] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
[9] Canc Registry Norway, Oslo, Norway
[10] Finnish Canc Registry, Canc Soc Finland, Helsinki, Finland
[11] Dana Farber Canc Inst, Boston Childrens Canc & Blood Disorders Ctr, Boston, MA 02115 USA
[12] Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark
[13] Aarhus Univ, Aarhus, Denmark
[14] NCI, Transdiv Res Program, Div Canc Epidemiol & Genet, Rockville, MD USA
关键词
Childhood cancer; birth defects; congenital anomalies; sex differences; cancer risk; DATA QUALITY; CONGENITAL-ANOMALIES; REGISTRY; PREVALENCE; COMPLETENESS; SYSTEMS; NORWAY;
D O I
10.1093/ije/dyac192
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Childhood cancer is more common among children with birth defects, suggesting a common aetiology. Whether this association differs by sex is unclear. Methods We performed a population-based nested case-control study using nationwide health registries in four Nordic countries. We included 21 898 cancer cases (0-19 years) and 218 980 matched population controls, born 1967-2014. Associations between childhood cancer and major birth defects were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) using logistic regression models. Effect modification was evaluated using a counterfactual framework to estimate confidence intervals and P-values for the natural indirect effects. Results Birth defects were present for 5.1% (1117/21 898) of childhood cancer cases and 2.2% (4873/218 980) of controls; OR of cancer was higher for chromosomal (OR = 10, 95% CI = 8.6-12) than for non-chromosomal defects (OR = 1.9, 95% CI = 1.8-2.1), strongest between genetic syndromes/microdeletion and renal tumours, Down syndrome and leukaemia, and nervous system defects and central nervous system tumours. The association between birth defects and cancer was stronger among females (OR = 2.8, 95% CI = 2.6-3.1) than males (OR = 2.1, 95% CI = 1.9-2.2, P-interaction <0.001). Male sex was an independent risk factor for childhood cancer, but very little of the overall association between sex and childhood cancer was mediated through birth defects (4.8%, P-NIE <0.001), although more at younger ages (10% below years and 28% below 1 year). Conclusions The birth defect-cancer associations were generally stronger among females than males. Birth defects did not act as a strong mediator for the modest differences in childhood cancer risk by sex, suggesting that other biological pathways are involved.
引用
收藏
页码:450 / 465
页数:16
相关论文
共 50 条
  • [21] Reproductive factors and risk of oesophageal cancer, a population-based nested case-control study in Sweden
    Lu, Y.
    Lagergren, J.
    BRITISH JOURNAL OF CANCER, 2012, 107 (03) : 564 - 569
  • [22] Calcium channel blockers and the risk for lung cancer: A population-based nested case-control study
    Rotshild, Victoria
    Laurent, Azoulay
    Feldhamer, Ilan
    Perlman, Amichai
    Glazer, Mendel
    Muszkat, Mordechai
    Matok, Ilan
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2018, 27 : 462 - 462
  • [23] Calcium Channel Blockers and the Risk for Lung Cancer: A Population-Based Nested Case-Control Study
    Rotshild, Victoria
    Azoulay, Laurent
    Feldhamer, Ilan
    Perlman, Amichai
    Glazer, Mendel
    Muszkat, Mordechai
    Matok, Ilan
    ANNALS OF PHARMACOTHERAPY, 2019, 53 (05) : 445 - 452
  • [24] The oral microbiome and prospective risk for esophageal cancer: A population-based nested case-control study
    Peters, Brandilyn A.
    Wu, Jing
    Pei, Zhiheng
    Yang, Liying
    Purdue, Mark P.
    Freedman, Neal D.
    Jacobs, Eric J.
    Gapstur, Susan M.
    Hayes, Richard B.
    Ahn, Jiyoung
    CANCER RESEARCH, 2017, 77
  • [25] Association between the risk of lung cancer and influenza: A population-based nested case-control study
    Weng, Ching-Fu
    Chen, Li-Ju
    Lin, Chih-Wan
    Chen, Ho-Min
    Lee, Henry Hsin-Chung
    Ling, Thai-Yen
    Hsiao, Fei-Yuan
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2019, 88 : 8 - 13
  • [26] Risk of childhood cancer with symptoms in primary care: a population-based case-control study
    Dommett, Rachel J.
    Redaniel, Theresa
    Stevens, Michael C. G.
    Martin, Richard M.
    Hamilton, William
    BRITISH JOURNAL OF GENERAL PRACTICE, 2013, 63 (606): : e22 - e29
  • [27] Birth weight and autism spectrum disorder: A population-based nested case-control study
    Talmi, Ziv
    Mankuta, David
    Raz, Raanan
    AUTISM RESEARCH, 2020, 13 (04) : 655 - 665
  • [28] Control Selection and Participation in an Ongoing, Population-based, Case-Control Study of Birth Defects
    Cogswell, Mary E.
    Bitsko, Rebecca H.
    Anderka, Marlene
    Caton, Alissa R.
    Feldkamp, Marcia L.
    Sherlock, Stacey M. Hockett
    Meyer, Robert E.
    Ramadhani, Tunu
    Robbins, James M.
    Shaw, Gary M.
    Mathews, T. J.
    Royle, Marjorie
    Reefhuis, Jennita
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2009, 170 (08) : 975 - 985
  • [29] Extreme winter temperature and birth defects: A population-based case-control study
    Van Zutphen, Alissa R.
    Hsu, Wan-Hsiang
    Lin, Shao
    ENVIRONMENTAL RESEARCH, 2014, 128 : 1 - 8
  • [30] A Population-Based Case-Control Study of Extreme Summer Temperature and Birth Defects
    Van Zutphen, Alissa R.
    Lin, Shao
    Fletcher, Barbara A.
    Hwang, Syni-An
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2012, 120 (10) : 1443 - 1449