A NEW METHOD OF PRODUCING PORTAL HYPERTENSION IN DOGS

In order to rind a simple but satisfying method to make animal model with portal hypertension, a new method is designed by constricting half of the POrtal lumen and embolizing the portalvein chronically with silk thread. Twenty-two dogs were used in the experiment, among which onedied, and the others’ portal venous pressure went up to (2. 83±0. 66) kpa 3～4 weeks arter the operation (1. 33±0.28) kpa before the operation (P < 0. 001 ). The results or gastrofiberscopic, portoveuographic and pathological examination showed that 17 dogs had esophagogastric varices with aformation rate or 80. 97 %. The 14 or which were achieved with a 100% formation rate as the methodwas improved. 12 dogs suffered portal hypertentive gastropathy (the rate of formation was57. 14% ). One dog was observed for 4 months arter the operation, still with portal hypertension. Allthis Indicates that the method is simple and time-saving, with high success rate, reliable quality andlong duration.