Continuous-flow synthesis of nitriles from aldehydes via Schmidt reaction

被引：0

作者：

Wei Zhan ^{[1
]}

Meng Tong ^{[1
]}

Ling Ji ^{[1
]}

Han Zhang ^{[1
]}

Zemei Ge ^{[1
]}

Xin Wang ^{[1
]}

Runtao Li ^{[1
]}

机构：

[1] State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University

来源：

Chinese Chemical Letters | 2019年 / 30卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Continuous-flow reaction; Aldehydes; Schmidt reaction; Nitriles; Safety;

D O I：

暂无

中图分类号：

TQ226.61 [];

学科分类号：

摘要：

A continuous-flow synthesis of nitriles by Schmidt reaction has been developed. Using this procedure, a variety of aldehydes could be smoothly transformed into the desired nitriles in good to excellent yields.The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up.

引用

页码：973 / 976

页数：4

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