Recent advances in target identification by natural product based chemical probes

被引：0
|
作者：
Benke Hong [1 ,2 ]
Ting Dong [3 ,4 ]
Xiaoguang Lei [1 ,3 ]
机构：
[1] Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering,Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University
[2] School of Pharmaceutical Science and Technology, Tianjin University
[3] National Institute of Biological Sciences
[4] Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences
来源：
Science China(Chemistry) | 2016年 / 09期
基金：
中国国家自然科学基金;
关键词：
natural product; chemical probe; chemical biology; target ID;
D O I：
暂无
中图分类号：
O629 [天然化合物];
学科分类号：
070303 ; 081704 ;
摘要：
Natural products have been extensively used to treat diseases throughout human history. These are mainly because natural products normally target biological macromolecules selectively. Target identification could help us to develop new therapeutic agents and discover new biological pathways underlying human diseases. Herein, we highlight some recent examples of using natural products and their derivatives as chemical probes to identify the molecular targets and elucidate mode of action.
引用
收藏
页码：1088 / 1092
页数：5
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