Facile access to β-hydroxyl ketones via a cobalt-catalyzed ring-opening/hydroxylation cascade of cyclopropanols

被引：0

作者：

Shengxian Zhai ^{[1
]}

Shuxian Qiu ^{[2
]}

Shuangtao Yang ^{[1
]}

Xingyuan Gao ^{[2
]}

Xinyu Feng ^{[1
]}

Chenzhe Yun ^{[1
]}

Ning Han ^{[1
]}

Yongsheng Niu ^{[1
]}

Jing Wang ^{[1
]}

Hongbin Zhai ^{[3
,4
,5
]}

机构：

[1] College of Chemistry & Environmental Engineering, Anyang Institute of Technology

[2] Department of Chemistry and Material Science, Engineering Technology Development Center of Advanced Materials & Energy Saving and Emission Reduction in Guangdong Colleges and Universities, Guangdong University of Education

[3] State Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics, Shenzhen Engineering Laboratory of Nano Drug Slow-Release, Shenzhen Graduate School of Peking University

[4] Shenzhen Bay Laboratory

[5] Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)

来源：

ChineseChemicalLetters | 2023年 / 34卷 / 03期

基金：

中国国家自然科学基金;

关键词：

D O I：

暂无

中图分类号：

TQ224.4 [醛和酮的功能衍生物];

学科分类号：

0817 ;

摘要：

A cobalt-catalyzed ring-opening/hydroxylation cascade of highly strained cyclopropanols has been developed for the first time. The reaction was conducted under open-air atmosphere to afford a broad series of structurally diverse β-hydroxy ketones in moderate to good yields with high regioselectivity.The protocol features mild reaction conditions, simple operation, high-functional-group tolerance, facile scalability, and heterocycle compatibility.

引用

页码：351 / 354

页数：4

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