Roles of chromatin assembly factor 1 in the epigenetic control of chromatin plasticity

被引：0
|
作者：
HUANG Hai1
2Graduate University of Chinese Academy of Sciences
机构：
来源：
Science China(Life Sciences) | 2012年 / 01期
基金：
中国国家自然科学基金;
关键词：
CAF-1; epigenetic information; chromatin plasticity; signal transduction; histone chaperone;
D O I：
暂无
中图分类号：
Q343 [细胞遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genetic information embedded in DNA sequence and the epigenetic information marked by modifications on DNA and histones are essential for the life of eukaryotes. Cells have evolved mechanisms of DNA duplication and chromatin restoration to ensure the inheritance of genetic and epigenetic information during cell division and development. In this review, we focus on the maintenance of epigenetic landscape during chromatin dynamics which requires the orchestration of histones and their chaperones. We discuss how epigenetic marks are re-established in the assembly of new chromatin after DNA replication and repair, highlighting the roles of CAF-1 in the process of changing chromatin state. The functions of CAF-1 provide a link between chromatin assembly and epigenetic restoration.
引用
收藏
页码：15 / 19
页数：5
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