A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

被引：0
|
作者：
ZHANG Jie [1 ]
WANG Chuan-Xi [2 ]
SONG Xiao-Jun [1 ]
LI Shuang [1 ]
ZHAO Huan [2 ]
CHEN Guo-Dong [2 ]
HU Dan [2 ]
GAO Hao [1 ,2 ]
YAO Xin-Sheng [1 ,2 ]
机构：
[1] College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
[2] Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University
来源：
Chinese Journal of Natural Medicines | 2019年 / 17卷 / 12期
基金：
中国国家自然科学基金;
关键词：
Tirucallane triterpenoid; Epimers; Picrasma quassioides; AChE inhibitory activity; Cytotoxicity; Antimicrobial activity;
D O I：
暂无
中图分类号：
R284 [中药化学];
学科分类号：
摘要：
A pair of new tirucallane triterpenoid epimers, picraquassins M and N(1 and 2), were isolated from the stems of Picrasma quassioides(D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their ACh E inhibitory activity, cytotoxicity against five human tumour cell lines(SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria(Staphylococcus. aureus 209 P and Escherichia coli ATCC0111) and two fungi(Candida albicans FIM709 and Aspergillus niger R330) were evaluated.
引用
收藏
页码：906 / 911
页数：6
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