A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides

被引：0

作者：

ZHANG Jie ^{[1
]}

WANG Chuan-Xi ^{[2
]}

SONG Xiao-Jun ^{[1
]}

LI Shuang ^{[1
]}

ZHAO Huan ^{[2
]}

CHEN Guo-Dong ^{[2
]}

HU Dan ^{[2
]}

GAO Hao ^{[1
,2
]}

YAO Xin-Sheng ^{[1
,2
]}

机构：

[1] College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University

[2] Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University

来源：

Chinese Journal of Natural Medicines | 2019年 / 17卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Tirucallane triterpenoid; Epimers; Picrasma quassioides; AChE inhibitory activity; Cytotoxicity; Antimicrobial activity;

D O I：

暂无

中图分类号：

R284 [中药化学];

学科分类号：

摘要：

A pair of new tirucallane triterpenoid epimers, picraquassins M and N(1 and 2), were isolated from the stems of Picrasma quassioides(D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their ACh E inhibitory activity, cytotoxicity against five human tumour cell lines(SW480, MCF-7, HepG2, Hela, and PANC-1), and antimicrobial activity against two bacteria(Staphylococcus. aureus 209 P and Escherichia coli ATCC0111) and two fungi(Candida albicans FIM709 and Aspergillus niger R330) were evaluated.

引用

页码：906 / 911

页数：6

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