Synthesis and Anti-inflammatory Activity of 2-(E)-(4-Hy-droxy-3-methoxybenzylidene)-5-(N-Substituted aminomethyl)Cyclopentanones

被引：1

作者：

董金华 ^{[1
]}

徐莉英 ^{[1
]}

秦华 ^{[1
]}

许丁元 ^{[1
]}

李莉 ^{[1
]}

计志忠 ^{[1
]}

机构：

[1] 沈阳药科大学

来源：

Journal of Chinese Pharmaceutical Sciences | 1998年 / 04期

关键词：

环戊酮衍生物; Mannich碱; 胺交换反应; 抗炎活性;

D O I：

暂无

中图分类号：

R914.5 [有机合成药物化学];

学科分类号：

100701 ;

摘要：

本文合成了１５种２（Ｅ）（３甲氧基４羟基苯亚甲基）环戊酮杂环胺Ｍａｎｎｉｃｈ碱盐酸盐和芳胺Ｍａｎｎｉｃｈ碱，并进行了初步的抗炎活性筛选。所有化合物结构均经波谱分析和元素分析证实。药理试验结果表明：部分化合物对二甲苯致小鼠耳肿胀有较显著的抑制作用；苯胺取代基的变化对芳胺Ｍａｎｎｉｃｈ碱的抗炎活性有显著的影响。

引用

页码：19 / 23

页数：5

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