An efficient synthesis of novel pyridothieno-fused thiazolo[3,2-α]pyrimidinones via Pictet–Spengler reaction

被引：2

作者：

Dao-Lin Wang ^{[1
]}

Dong Wang ^{[1
]}

Liang Yan ^{[1
]}

Guang-Yu Pan ^{[1
]}

Jian-Nan Yang ^{[1
]}

机构：

[1] College of Chemistry and Chemical Engineering, Liaoning Key Laboratory of Synthesis and Application of Functional Compound,Bohai University

来源：

Chinese Chemical Letters | 2016年 / 27卷 / 06期

关键词：

7-Chloromethyl-5H-thiazolo[3,2-α]pyrimidin-5-one; 3-Cyanopyridine-2-thione; Pyrido[3’’,2’’,4’,5’]thieno[3’,2’,2,3]pyrido; 4,5:d] [1,3]Thiazolo[3,2-a]pyrimidine-4 one; Thorpe–Ziegler reaction; Pictet–Spengler reaction;

D O I：

暂无

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of novel pyrido[3’’,2’’:4’,5’]thieno[3’,2’:2,3]pyrido [4,5:d][1,3]thiazolo[3,2-a]pyrimidine-4-one derivatives(5) has been developed using a Pictet–Spengler reaction between 2-(3-aminothieno[2,3-b]pyridin-2-yl)thiazolo[3,2-a] pyrimidin-5-one(3), which could be obtained from the condensation of 7-(chloromethyl)-5H-thiazolo[3,2-a]pyrimidin-5-one(1) with3-cyanopyridine-2-thione(2) via Thorpe–Ziegler isomerization, and aromatic aldehydes under NHSOH as catalysis in good yields.

引用

页码：953 / 956

页数：4

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