Localization of RanBP1 in Early Embryonic Development of Mice

被引：0
|
作者：
Hu Xiao-yang [1 ]
Zeng Xiao [1 ]
Xu Ying [1 ]
Ding Cong [1 ]
Zhang Dan-dan [1 ]
Jia Zhen-zhen [1 ]
Cao Yun-kao [1 ]
机构：
[1] Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University
来源：
JournalofNortheastAgriculturalUniversity(EnglishEdition) | 2020年 / 27卷 / 02期
关键词：
RanBP1; confocal microscopy; localization; mouse; early embryonic development;
D O I：
暂无
中图分类号：
Q132 [普通胚胎学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
RanBP1 is a binding protein of Ran that plays a pivotal role in nucleocytoplasmic transport.In this study,the localization and possible functions of RanBP1 were examined,during the early embryonic development of mice.Immunofluorescence results showed that RanBP1 was mainly localized in cytoplasm at mitosis interphase,and its concentration was lower in nucleus and the lowest in nucleolus.With the formation of the spindle in the early embryonic cells,RanBP1 condensed area took the shape of spindle microtubule,the concentration of RanBP1 was low in the site of chromosome.During the formation of nucleus,RanBP1 concentrated in nucleus and there were few dots of RanBP1 around the nucleolus.These dots were lost after the nucleus full growth.The results showed that RanBP1 had important roles in nucleocytoplasmic transport,spindle formation and nuclear assembly in the early embryonic development of mice.
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页码：116 / 121
页数：6
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