RELATIONSHIPS BETWEEN IONIZING RADIATION,BONE MARROW TRANSPLANTATION AND LEUKEMOGENESIS

被引:0
|
作者
朴长青
葛淑清
杨媛
机构
[1] Beijing
[2] Ministry of Public Health
[3] Laboratory of Industrial Hygiene
[4] PRC
关键词
RELATIONSHIPS BETWEEN IONIZING RADIATION; BONE MARROW TRANSPLANTATION AND LEUKEMOGENESIS;
D O I
暂无
中图分类号
学科分类号
摘要
Studies of the relationships between ionizing radiation, bone marrow transplantation and leukemo-genesis were carried out in 343 LACA mice. The recipients (female) were given whole-body irradiationwith 7 or 8 Cy of Co-60 γ-rays, while the donors (male) were given whole-body irradiation with 3, 1.5,0.5, 0.1, 0.05 and 0 Gy of Co-60 γ-rays. Each recipient was intravenously infused with 1-3 ×10of themixed marrow cells of donors. In the result, the average incidence of surviving over 1 month was 86% inthe recipients. Myelocytic leukemia developed in all the transplanted groups, the average incidence being88.5%. Leukemia was observed in 1.5-2.5 months after transplantation in the recipients receiving marrowcells from donors exposed to 3 Gy, but in 5-8 months in other groups. It was demonstrated by the analysis of Y-chromosome that the leukemic cells were derived from the donor’s marrow cells. The resultssuggest that marrow transplantation for the mice irradiated by Co-60 γ-rays of lethal dose can prote
引用
收藏
页码:161 / 168
页数:8
相关论文
共 50 条
  • [11] Longterm effects of ionizing radiation upon bone marrow stroma and hemopoiesis
    Brockbank, K.G.M.
    Ploemacher, R.E.
    Piersma, A.H.
    Brons, N.H.C.
    Proceedings of the International Congress of Radiation Research, 1984, : 1 - 05
  • [12] Bone marrow transplantation retinopathy in the absence of radiation therapy
    Cunningham, ET
    Irvine, AR
    Rugo, HS
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 1996, 122 (02) : 268 - 270
  • [13] RADIATION NEPHRITIS FOLLOWING BONE-MARROW TRANSPLANTATION
    KAMIL, ES
    LATTA, H
    JOHNSTON, WH
    FEIG, SA
    BERGSTEIN, JM
    KIDNEY INTERNATIONAL, 1978, 14 (06) : 713 - 713
  • [14] RADIATION NEPHRITIS FOLLOWING BONE-MARROW TRANSPLANTATION
    KAMIL, ES
    LATTA, H
    JOHNSTON, WH
    FEIG, SA
    BERGSTEIN, JM
    CLINICAL RESEARCH, 1979, 27 (01): : A133 - A133
  • [15] RADIATION NEPHRITIS IN SURVIVORS OF BONE-MARROW TRANSPLANTATION
    WEINSTEIN, H
    GUINAN, E
    TARBELL, N
    NIEMEYER, C
    COTRAN, R
    KRETSCHMAR, C
    SALLAN, S
    MEDICAL AND PEDIATRIC ONCOLOGY, 1987, 15 (06): : 330 - 330
  • [16] Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models
    Noriko Doki
    Jiro Kitaura
    Tomoyuki Uchida
    Daichi Inoue
    Yuki Kagiyama
    Katsuhiro Togami
    Masamichi Isobe
    Shinichi Ito
    Akie Maehara
    Kumi Izawa
    Naoko Kato
    Toshihiko Oki
    Yuka Harada
    Fumio Nakahara
    Hironori Harada
    Toshio Kitamura
    International Journal of Hematology, 2012, 95 : 167 - 175
  • [17] Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models
    Doki, Noriko
    Kitaura, Jiro
    Uchida, Tomoyuki
    Inoue, Daichi
    Kagiyama, Yuki
    Togami, Katsuhiro
    Isobe, Masamichi
    Ito, Shinichi
    Maehara, Akie
    Izawa, Kumi
    Kato, Naoko
    Oki, Toshihiko
    Harada, Yuka
    Nakahara, Fumio
    Harada, Hironori
    Kitamura, Toshio
    INTERNATIONAL JOURNAL OF HEMATOLOGY, 2012, 95 (02) : 167 - 175
  • [18] DOSE LOADS ON THE BONE-MARROW DURING THE EFFECT OF IONIZING-RADIATION
    MURASHOV, BF
    KOROLYOV, VI
    FEIGIN, LG
    VRACHEBNOE DELO, 1991, (09): : 64 - 67
  • [19] Effects of ionizing radiation on differentiation of murine bone marrow cells into mast cells
    Murakami, Sho
    Yoshino, Hironori
    Ishikawa, Junya
    Yamaguchi, Masaru
    Tsujiguchi, Takakiyo
    Nishiyama, Ayaka
    Yokoyama, Kouki
    Kashiwakura, Ikuo
    JOURNAL OF RADIATION RESEARCH, 2015, 56 (06) : 865 - 871
  • [20] Role of bone marrow derived cells in response to ionizing radiation in normal brain
    Burrell, Kelly
    Jelveh, Salomeh
    Jalall, Shahrzad
    Hill, Richard
    Zadeh, Gelareh
    CANCER RESEARCH, 2011, 71