126Gln is the residue of human IL-2 binding to IL-2R γ subunit

被引：0
|
作者：
王志勇
郑仲承
孙兰英
刘新垣
机构：
[1] Shanghai Institute of Biochemistry
[2] Chinese Academy of Sciences Shanghai 200031
[3] China
来源：
Science in China(Series C:Life Sciences) | 1997年 / 02期
关键词：
IL-2; IL-2R; binding siu;
D O I：
暂无
中图分类号：
Q987 [人类遗传学];
学科分类号：
071007 ;
摘要：
The 126Gln of human interleukin-2 (IL-2) is a conserved amino acid residue. After substitution of 126Gln with Asp, the binding abilities of this mutant to different composites of IL-2 receptor (R) subunits have been determined. Results show that 126Asp-IL-2 has higher affinity to IL-2R α βγ complex and normal affinity to IL-2R α β complex, but loses its binding ability to IL-2R β γ complex, demonstrating that the 126Gln is the residue of human IL-2 which binds to IL-2R 7 subunit.
引用
收藏
页码：159 / 168
页数：10
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