Precise nanomedicine for intelligent therapy of cancer

被引：0

作者：

Huabing Chen ^{[1
]}

Zhanjun Gu ^{[2
]}

Hongwei An ^{[2
,3
]}

Chunying Chen ^{[3
,4
]}

Jie Chen ^{[5
,6
,7
]}

Ran Cui ^{[8
]}

Siqin Chen ^{[9
]}

Weihai Chen ^{[10
]}

Xuesi Chen ^{[5
,6
,7
]}

Xiaoyuan Chen ^{[11
]}

Zhuo Chen ^{[12
]}

Baoquan Ding ^{[3
]}

Qian Dong ^{[12
]}

Qin Fan ^{[13
]}

Ting Fu ^{[12
]}

Dayong Hou ^{[3
]}

Qiao Jiang ^{[3
]}

Hengte Ke ^{[1
]}

Xiqun Jiang ^{[14
]}

Gang Liu ^{[15
]}

Suping Li ^{[3
]}

Tianyu Li ^{[16
]}

Zhuang Liu ^{[13
]}

Guangjun Nie ^{[3
]}

Muhammad Ovais ^{[3
,4
]}

Daiwen Pang ^{[8
]}

Nasha Qiu ^{[9
]}

Youqing Shen ^{[9
]}

Huayu Tian ^{[5
,6
,7
]}

Chao Wang ^{[13
]}

Hao Wang ^{[3
]}

Ziqi Wang ^{[3
]}

Huaping Xu ^{[16
]}

Jiang-Fei Xu ^{[16
]}

Xiangliang Yang ^{[17
]}

Shuang Zhu ^{[2
]}

Xianchuang Zheng ^{[14
]}

Xianzheng Zhang ^{[10
]}

Yanbing Zhao ^{[17
]}

Weihong Tan ^{[12
,18
]}

Xi Zhang ^{[16
]}

Yuliang Zhao ^{[3
]}

机构：

[1] Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University

[2] Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health

[3] Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University

[4] Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials, Soochow University

[5] Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University

[6] State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine,School of Public Health, Xiamen University

[7] Department of Chemistry, Tsinghua University

[8] National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology

[9] Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida

[10] State Key Laboratory of Radiation Medicine and Protection, Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University

[11] Institute of High Energy Physics, Chinese Academy of Sciences

[12] CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China

[13] University of Chinese Academy of Sciences

[14] Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences

[15] University of Science and Technology of China

[16] Jilin Biomedical Polymers Engineering Laboratory

[17] Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, State Key Laboratory of Virology, and Institute for Advanced Studies, Wuhan University

[18] Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University

来源：

Science China(Chemistry) | 2018年 / 61卷 / 12期

基金：

中国国家自然科学基金;

关键词：

nanomedicine; nanoparticles; cancer therapy; cancer imaging; intelligent therapy;

D O I：

暂无

中图分类号：

R730.5 [肿瘤治疗学]; TB383.1 [];

学科分类号：

摘要：

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

引用

页码：1503 / 1552

页数：50

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