Synthesis and Cytotoxic Activity of Novel Water-soluble Prodrugs of Combretastatin A-4

被引：0
|
作者：
Zhi Quan YONG
机构：
来源：
ChineseChemicalLetters | 2006年 / 01期
关键词：
Combretastatin A-4; cytotoxicity; phosphoryl choline; water-soluble; prodrug;
D O I：
暂无
中图分类号：
TQ464 [生物制品药物的生产];
学科分类号：
100705 ;
摘要：
Novel water-soluble prodrugs of combretastatin A-4 (5-8) were synthesized and evaluated for their in vitro cytotoxicity against lung carcinoma A549. Compound 5, bearing phosphoryl choline (PC) moiety, showed 90% inhibition at 32 μg/mL concentration after 24 h. The findings showed the PC derivative would be a promising candidate for the development of new water-soluble prodrug of cytotoxic combretastatin A-4.
引用
收藏
页码：23 / 26
页数：4
相关论文
共 50 条
  • [31] Design, stereoselective synthesis, and antitumoral activity of combretastatin A-4 analogs
    da Silva, Wilson P.
    Caiana, Robrigo R. A.
    Barros, Maria E. S. B.
    Freitas, Juliano C. R.
    da Silva, Paulo B. N.
    Milita, Gardenia G. C.
    Oliveira, Roberta A.
    Menezes, Paulo H.
    RESULTS IN CHEMISTRY, 2024, 7
  • [32] Design, synthesis, and anti-breast tumor activity of novel combretastatin A-4 analogues
    Gao, Yiting
    Li, Jinfang
    Ma, Teng
    MONATSHEFTE FUR CHEMIE, 2023, 154 (11): : 1285 - 1294
  • [33] Design, synthesis, and anti-breast tumor activity of novel combretastatin A-4 analogues
    Yiting Gao
    Jinfang Li
    Teng Ma
    Monatshefte für Chemie - Chemical Monthly, 2023, 154 : 1285 - 1294
  • [34] Synthesis and in vitro biological activity evaluation of the derivatives of combretastatin A-4
    Yang, Zhaoqi
    LETTERS IN DRUG DESIGN & DISCOVERY, 2006, 3 (08) : 544 - 546
  • [35] Synthesis and biological evaluation of novel heterocyclic derivatives of combretastatin A-4
    Thi Thanh Binh Nguyen
    Lomberget, Thierry
    Ngoc Chau Tran
    Colomb, Evelyne
    Nachtergaele, Lore
    Thoret, Sylviane
    Dubois, Joelle
    Guillaume, Joren
    Abdayem, Rawad
    Haftek, Marek
    Barret, Roland
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (23) : 7227 - 7231
  • [36] Synthesis and antitumor activity of water-soluble duocarmycin B1 prodrugs
    Asai, A
    Nagamura, S
    Kobayashi, E
    Gomi, K
    Saito, H
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (20) : 2995 - 2998
  • [37] SYNTHESIS OF CONGENERS AND PRODRUGS .3. WATER-SOLUBLE PRODRUGS OF TAXOL WITH POTENT ANTITUMOR-ACTIVITY
    DEUTSCH, HM
    GLINSKI, JA
    HERNANDEZ, M
    HAUGWITZ, RD
    NARAYANAN, VL
    SUFFNESS, M
    ZALKOW, LH
    JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (04) : 788 - 792
  • [38] Synthesis and cytotoxic activity of novel conformationally restricted analogs of Combretastatin A4
    Aly, Omar M.
    Beshr, Eman A.
    Mostafa, Raed
    Mostafa, Mohamed
    Kaood, Tamer S.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [39] Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4
    Tang, Yan
    Tu, Zhewei
    Sun, Jing
    Zhu, Xiong
    Liu, Kun
    He, Shuying
    Xu, Yungen
    LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10 (10) : 935 - 941
  • [40] Novel Combretastatin A-4 Analogs-Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity
    Jedrzejczyk, Marta
    Morabito, Benedetta
    Zyzynska-Granica, Barbara
    Struga, Marta
    Janczak, Jan
    Aminpour, Maral
    Tuszynski, Jack A.
    Huczynski, Adam
    MOLECULES, 2024, 29 (10):
12345