Synthesis of fluorescent bisboronic acid sensors and their recognition of mono-/oligo-saccharides

被引：0

作者：

Yan-En Wang ^{[1
,2
]}

Rui-Xue Rong ^{[1
,3
]}

Hua Chen ^{[1
]}

Meng-Yuan Zhu ^{[4
]}

Bing-He Wang ^{[4
]}

Xiao-Liu Li ^{[1
]}

机构：

[1] Key Laboratory of Chemical Biology of Hebei Province,College of Chemistry and Environmental Science,Hebei University

[2] College of Science,Agricultural University of Hebei

[3] Medical School,Hebei University

[4] Department of Chemistry and Center for Diagnostics and Therapeutics,Georgia State University

来源：

ChineseChemicalLetters | 2017年 / 28卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Lewis sugars; Bisboronic acid; Shinkai’s anthracene-based fluorescent; sensor; Biochemical recognition; Synthesis;

D O I：

暂无

中图分类号：

O657.3 [光化学分析法（光谱分析法）]; TP212 [发送器（变换器）、传感器];

学科分类号：

080202 ;

摘要：

Sensors capable of recognizing cell surface carbohydrates,such as sialyl Lewis X（sLe;）,are invaluable research tools and for the diagnosis and early detection of many forms of cancer.In this paper,we report the design and synthesis of a series of bisboronic acids 6（a-f） as fluorescent sensors towards mono-/oligosaccharides.Among them,compounds 6d and 6e showed strong binding affinities with glucose and fructose,while compound 6c,in which two anthracene-based boronic acid units were linked by a hexamethylene spacer,was able to recognize sLe;selectivity and stained HEPG2 cells at 1 μmoI/L.

引用

页码：1262 / 1267

页数：6

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