Synthesis of 14-epi-19-nor-22-oxa-1α,25-dihydroxyvitamin D3

被引：0
|
作者：
Wei Fan Li Hai Yong Wu Key Laboratory of Drag Targeting of Education Ministry
机构：
来源：
Chinese Chemical Letters | 2008年 / 03期
关键词：
1α; 25-Dihydroxyvitamin D3; 14-Epi-19-nor-22-oxa-1α; 25-dihydroxyvitamin D3; Device; Synthesis;
D O I：
暂无
中图分类号：
O621.3 [有机合成化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 14-epi-19-nor-22-oxa-1α,25（OH）;D;5 was started from diol 8 via Fall’s method,oxidation,epimerization, protection,coupling with the 19-nor-A-ring 7,and then deprotection of the hydroxyl functions.
引用
收藏
页码：259 / 260
页数：2
相关论文
共 50 条
  • [1] Synthesis of 14-epi-19-nor-22-oxa-1α,25-dihydroxyvitamin D3
    Wei Fan
    Li Hai
    Yong Wu
    CHINESE CHEMICAL LETTERS, 2008, 19 (03) : 259 - 260
  • [2] A practical synthesis of 14-epi-19-nor-1a,25-dihydroxyvitamin D3 analogues and their A-ring epimers
    Wu, YS
    Zhao, YR
    Tian, HJ
    De Clercq, P
    Vandewalle, M
    Berthier, M
    Pellegrino, G
    Maillos, P
    Pascal, JC
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2001, 2001 (20) : 3779 - 3788
  • [3] Synthesis of 21-nor-22-oxa-1α,25-dihydroxyvitamin D3 derivatives in quest of a drug with low calcemic activity
    Shimizu, H
    Shimizu, K
    Uchiyama, Y
    Sugita, A
    Mikami, T
    Yamauchi, T
    Kato, M
    Morikawa, K
    TETRAHEDRON LETTERS, 2004, 45 (42) : 7837 - 7841
  • [4] Synthesis of 2-Ethyl-19-nor Analogs of 1α,25-Dihydroxyvitamin D3
    Laplace, Duchan R.
    Van Overschelde, Michel
    De Clercq, Pierre J.
    Verstuyf, Annemieke
    Winne, Johan M.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2013 (04) : 728 - 735
  • [5] The synthesis of A-ring synthon for 19-Nor-1α,25-dihydroxyvitamin D3
    Wu, Y
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 1999, 19 (04) : 374 - 378
  • [6] Singly dehydroxylated a-ring analogues of 19-nor-1α-25-dihydroxyvitamin D3 and 19-nor-22-oxa-1α,25-dihydroxyvitamin D3:: Novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor
    Okano, T
    Nakagawa, K
    Tsugawa, N
    Ozono, K
    Kubodera, N
    Osawa, A
    Terada, M
    Mikami, K
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 1998, 21 (12) : 1300 - 1305
  • [7] Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1α,25-dihydroxyvitamin D3:: Synthesis and biological evaluation
    Posner, GH
    Crawford, K
    Siu-Caldera, ML
    Reddy, GS
    Sarabia, SF
    Feldman, D
    van Etten, E
    Mathieu, C
    Gennaro, L
    Vouros, P
    Peleg, S
    Dolan, PM
    Kensler, TW
    JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (19) : 3581 - 3586
  • [8] Synthesis of an intermediate for A-ring of 19-nor-1α,25-dihydroxyvitamin D3 analogues
    Wu, Y
    Guan, M
    Ji, T
    Cheng, L
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2001, 40 (02): : 136 - 138
  • [9] A practical synthesis of a-ring precursors for 19-nor-1a,25-dihydroxyvitamin D3 analogues
    Tetrahedron Lett, 42 (7637):
  • [10] Synthesis of an optically active intermediate for A-ring of 19-nor-1α,25-dihydroxyvitamin D3
    Shan Qian
    Chinese Chemical Letters, 2007, (03) : 261 - 262
12345