High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese

Objective To describe the distribu on of plasma high sensi vity C-reac ve protein (hsCRP) and explore the rela onship between hsCRP and metabolic risk factors among residents living in longevity areas of China.Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to par cipate in a cross sec on longitudinal cohort study.The par cipants were interviewed with general health related ques onnaire to collect their demographic,behavioral and lifestyle data,as well as their chronic condi ons,and meanwhile their physical and biomedical parameters including waist circumference (WC),blood pressure (BP),hsCRP,plasma lipids,and fas ng blood glucose (FBG) were measured.Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 1.76 mg/L in the oldest old group.No significant gender difference was observed between the above two groups.Among the oldest old individuals,36.56% had an hsCRP level >3.0 mg/L.The prevalence of high hsCRP was 16.79% in the middle-aged group.The results of stepwise mul ple linear regression analyses showed that HDL-C was independently associated with ln (hsCRP) concentra on in the middle-aged group,whereas ln (TG),HDL-C and FBG were correlated a er adjustment for gender,study site,smoking,drinking,educa on and BMI in the oldest old group.Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged popula on.For the oldest old persons,high TG,low HDL-C,and FBG predict elevated plasma hsCRP.