Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C-H bond activation

被引：0

作者：

Miao-Miao Chen ^{[1
]}

Ling-Yan Shao ^{[1
]}

Li-Jun Lun ^{[2
]}

Yu-Liang Wu ^{[2
]}

Xiao-Pan Fu ^{[1
]}

Ya-Fei Ji ^{[1
]}

机构：

[1] School of Pharmacy, East China University of Science & Technology

[2] Shandong Keyuan Pharmaceutical Co., Ltd., Shandong Shanghe Economic Development Zone

来源：

Chinese Chemical Letters | 2019年 / 30卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Palladium-catalysis; Late-stage functionalization; AroYlation; Fully substituted pyrazoles; C-H bond activation; Cyclopalladated intermediate;

D O I：

暂无

中图分类号：

O621.251 [];

学科分类号：

摘要：

The palladium-catalyzed late-stage aroylation of 4-methyl-1,5-diaryl-lH-pyrazole-3-carboxylates has been developed via direct and exclusive mono-Csp;-H bond activation with broad substrate scope and good functional group tolerance. A dual-core dimeric palladacycle is confirmed by X-ray single crystal crystallography, and probably serves as an active species in the catalytic cycle.

引用

页码：702 / 706

页数：5

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