Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

被引：0
|
作者：
Kuo-Ching Yang
Alexander Chu
机构：
[1] Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su MemorialHospital
[2] Taipei Taiwan China
来源：
World Journal of Gastroenterology | 2006年 / 43期
关键词：
Western blot; immunoblotting; Gastric cancer; H pylori; enzyme-linked immunosorbent assay;
D O I：
暂无
中图分类号：
R735.2 [胃肿瘤];
学科分类号：
100214 ;
摘要：
AIM: To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. METHODS: A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy: normal control group (25 patients) and gastric cancer group (29 patients). Both groups were further divided into H pylori (+) and H pylori (-) subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique (HelicoBlot 2.0, Genelabs Diagnostics, Singapore). RESULTS: The positive rate of the immunoblotting test was as high as 88.9% in the H pylori (-) gastric cancer group and only 14.3% in the H pylori (-) normal control group with a statistically significant difference. CONCLUSION: The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.
引用
收藏
页码：7029 / 7032
页数：4
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