Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation

被引：0
|
作者：
Chuanshi He [1 ]
Ling Li [1 ]
Linlin Wang [1 ]
Wanrong Meng [1 ]
Yaying Hao [1 ]
Guiquan Zhu [2 ]
机构：
[1] Department of Stomatology, Sichuan Cancer Hospital, Sichuan Key Laboratory of Radiation Oncology, School of Medicine,University of Electronic Science and Technology of China
[2] State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University
来源：
Cancer Biology & Medicine | 2021年 / 18卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R730.5 [肿瘤治疗学];
学科分类号：
100214 ;
摘要：
Radiotherapy is one of the most effective treatment methods for various solid tumors. Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness. Exosomes, initially considered as "garbage bins" for unwanted from cells, are now understood to perform a variety of functions in interactions within the tumor microenvironment. Exosome-mediated regulation processes are rebuilt under the irradiation stimuli, because the exosome production, uptake, and contents are markedly modified by irradiation. In turn, irradiation-modified exosomes may modulate the cell response to irradiation through feedback regulation. Here, we review current knowledge and discuss the roles of exosome-mediated interactions between cells under radiotherapy conditions.
引用
收藏
页码：21 / 33
页数：13
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