Efficient One-pot Synthesis of Pyrrolo[2,1-a]isoquinoline and Pyrrolo[1,2-a]quinoline Derivatives

被引：0
|
作者：
LIU Zhen-ming 1
机构：
来源：
Chemical Research in Chinese Universities | 2012年 / 28卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Indolizine; Pyrrolo[2,1-a]isoquinoline; One-pot reaction; Three-component reaction;
D O I：
暂无
中图分类号：
TQ25 [杂环化合物的生产];
学科分类号：
摘要：
A one-pot sequential reaction for efficient synthesis of pyrrolo[2,1-a]isoquinoline and pyrrolo[1,2-a]quinoline derivatives has been developed.The reaction included firstly the Cu-catalyzed three-component reaction of isoquinoline(quinoline),acetylenedicarboxylate and alkynylbenzene and then Cs 2 CO 3-promoted intramolecular cyclization reaction of initially formed 1-alkenyl-2-alkynyl-1,2-dihydroisoquinoline(1,2-dihydroquinoline).
引用
收藏
页码：990 / 993
页数：4
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