Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid

被引：0
|
作者：
Yulie Xu [1 ,2 ]
Yancheng Liu [1 ]
Haixia Li [1 ]
Peng Zhang [1 ]
Jianfeng Zhao [1 ,2 ]
Wenfeng Wang [1 ]
机构：
[1] Shanghai Institute of Applied Physics, Chinese Academy of Sciences
[2] University of Chinese Academy of Sciences
来源：
Science China Chemistry | 2015年 / 03期
基金：
中国国家自然科学基金;
关键词：
lysozyme; pazufloxacin; ferulic acid; laser flash photolysis; pulse radiolysis; SDS-PAGE;
D O I：
暂无
中图分类号：
TQ460.1 [基础理论];
学科分类号：
1007 ;
摘要：
Laser flash photolysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) experiments were carried out to study the photosensitive damage induced by pazufloxacin(PAX) and the protection of lysozyme(Lyso) by ferulic acid(FCA), an active antioxidant. Transient absorption spectra revealed electron transfer from Lyso and FCA to 3PAX*, with respective bimolecular reaction rate constants of 6.3×107 and 1.4×1010 dm3/(mol s). A pulse radiolysis study was also performed to investigate the formation of Lyso radical cations. Results showed that FCA effectively inhibited the cross-linking of protein induced by fluoroquinolones. Finally, a mechanism of the protective effect of FCA on Lyso was proposed.
引用
收藏
页码：508 / 513
页数：6
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