Effects of Electroacupuncture on Expression of COX-2 in the Dorsal Horn of Spinal Cord of Arthritic Rats

被引：0

作者：

徐红 ^{[1
]}

王彦青 ^{[2
]}

汪军 ^{[2
]}

俞瑾 ^{[2
]}

吴根诚 ^{[2
]}

朱忠春

机构：

[1] Department of Integrated Traditional and Western Medicine,Institute of Acupuncture Mechanism.Shanghai Medical College,Fudan University,Shanghai 200032,P.R.China Department of Acupuncture and Moxibustion,Longhua Hospital Affiliated to Shanghai University of

[2] Department of Integrated Traditional and Western Medicine,Institute of Acupuncture Mechanism,Shanghai Medical College,Fudan University,Shanghai 200032,P.R.China

来源：

Journal of Acupuncture and Tuina Science | 2006年 / 4卷 / 05期

关键词：

电针; 完全弗氏佐剂; 关节炎; 脊髓背角; 环氧合酶-2;

D O I：

暂无

中图分类号：

R245 [针灸学、针灸疗法];

学科分类号：

100512 ;

摘要：

目的:本工作试图通过观察慢性炎症痛大鼠脊髓背角环氧合酶(COX-2)蛋白表达的变化,探讨脊髓背角 COX-2是否与电针镇痛的作用机制有关。方法:在佐剂性关节炎大鼠的模型上,采用行为学和免疫组化技术两种方法,观察电针治疗后不同时相关节炎大鼠的痛敏评分及脊髓背角 COX-2蛋白的表达,并与正常组、模型组和药物组加以对照。结果:电针能明显减小关节炎大鼠痛敏评分的绝对值。多次电针具有显著的累积效应;并且随着电针治疗次数的增加,大鼠脊髓背角 COX-2免疫阳性细胞数显著下降。结论:电针阳陵泉和昆仑两穴对佐剂性关节炎大鼠有明显的镇痛作用,并同时抑制其脊髓背角 COX-2蛋白的表达。

引用

页码：264 / 266

页数：3

共 50 条

[31] Expression of nerve growth factor in spinal dorsal horn following crushed spinal cord injury
中国病理生理杂志, 2001, (08) : 97 - 97
[32] Involvement of both COX-1 and COX-2 in formalin evoked nociceptive behavior and prostaglandin release in the dorsal horns of the spinal cord
Vetter, G
Bräutigam, L
Geisslinger, G
Tegeder, I
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2001, 363 (04) : R90 - R90
[33] Effect of Electroacupuncture on Neurotrophin Expression in Cat Spinal Cord after Partial Dorsal Rhizotomy
Ting-Hua Wang
Xu-Yang Wang
Xiao-Li Li
Hong-Ming Chen
Liang-Fang Wu
Neurochemical Research, 2007, 32 : 1415 - 1422
[34] Effect of electroacupuncture on neurotrophin expression in cat spinal cord after partial dorsal rhizotomy
Wang, Ting-Hua
Wang, Xu-Yang
Li, Xiao-Li
Chen, Hong-Ming
Wu, Liang-Fang
NEUROCHEMICAL RESEARCH, 2007, 32 (08) : 1415 - 1422
[35] Decoy intervention modulates COX-2 and iNOS expression after spinal cord contusion injury
Rafati, DS
Perez-Polo, JR
JOURNAL OF NEUROTRAUMA, 2003, 20 (10) : 1073 - 1073
[36] Electroacupuncture Relieves Neuropathic Pain via Adenosine 3 Receptor Activation in the Spinal Cord Dorsal Horn of Mice
Kiani, Faisal Ayub
Li, Hao
Nan, Sha
Li, Qiuhua
Lei, Qianghui
Yin, Ruiling
Cao, Shiya
Ding, Mingxing
Ding, Yi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (19)
[37] Changes in expression of nociceptin/orphanin FQ and its receptor in spinal dorsal horn during electroacupuncture treatment for peripheral inflammatory pain in rats
Fu, Xin
Wang, Yan-Qing
Wang, Jun
Yu, Jin
Wu, Gen-Cheng
PEPTIDES, 2007, 28 (06) : 1220 - 1228
[38] Electroacupuncture alleviates diabetes-induced mechanical allodynia and downregulates bradykinin B1 receptor expression in spinal cord dorsal horn
Chi, Hengyu
Hu, Qunqi
Li, Xiang
Kang, Yurong
Zheng, Yu
Jiang, Mingjian
Xu, Xinnan
Wang, Xiaoxiang
He, Xiaofen
NEUROREPORT, 2024, 35 (11) : 692 - 701
[39] Nitrous oxide activates GABAergic interneurons in the dorsal horn of the spinal cord in fischer rats
Hashimoto, T
Maze, M
Fyjinaga, M
ANESTHESIOLOGY, 2000, 93 (3A) : U193 - U193
[40] Nitrous oxide increases release of norepinephrine in the dorsal horn of the spinal cord in awake rats
Zhang, C
Davies, MF
Maze, M
ANESTHESIOLOGY, 1998, 89 (3A) : U195 - U195

← 1 2 3 4 5 →