Apolipoprotein E genotype in patients with Alzheimer's disease

被引：0
|
作者：
罗本燕
陈智
张艳艳
潘小平
李霞
陈峰
机构：
[1] Department of Neurology
[2] First Affiliated Hospital
[3] Medical College of Zhejiang University
[4] Institute of Infectious Diseases
[5] Medical College of Zhejiang University Hangzhou 310003
[6] China
来源：
中华医学杂志(英文版) | 2003年 / 08期
关键词：
Alzheimer disease·genetics·apolipoprotein E · single nucleotide polymorphism;
D O I：
暂无
中图分类号：
R749.1 [脑器质性精神障碍];
学科分类号：
100205 ;
摘要：
Objective To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer’s disease (AD).Methods Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls,using PCR and gene sequencing.Results The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD ( P <0.05).Conclusions The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.
引用
收藏
页码：99 / 101
页数：3
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