THE STUDY ON RELATIONSHIP BETWEEN CIGARETTE SMOKING AND THE p53 PROTEIN AND P21 PROTEIN EXPRESSION IN NON-SMALL LUNG CANCER

This paper discusses the relationship betweencigarette smoking and the p53 protein and P21 proteinexpression by the immunohistochemical analysis in 93cases with lung cancer in which squamous cell carcinomaaccounted for 45 cases, adenocarcinoma 48 cases. Theresults showed that positive proportion of p53 proteinexpression was 74.20% (28 of 37 squamous cell carcinoma,21 of 30 adenocarcinomas) in cigarette smoking groupwith lung cancers, and 38.46% (3 of 8 squamous cellcarcinoma, 7 of 18 adenocarcinomas) in nonsmokinggroup with lung cancers. The difference was statisticallysignificant. Odds ratio was 4.14 and confidence limitsfor OR was 1.42-12.52. A dose-related presents in thep53 protein expression for the smoking amount andsmoking years. The positive proportion of P21 proteinexpression was 79.31% (21 of 28 squamous cell carcinoma,25 of 30 adenocarcinomas) in cigarette smoking groupwith lung cancers, and 82.75%(10 of 11 squamous,14 of18 adenocarcinomas) in nonsmoking group with lungcancers, the difference