Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway

被引：0
|
作者：
Yang Yang [1 ]
Zi-Jian Zhang [1 ]
Yu Wen [1 ]
Li Xiong [1 ]
Yun-Peng Huang [1 ]
Yong-Xiang Wang [1 ]
Kai Liu [1 ]
机构：
[1] Department of General Surgery, The Second Xiangya Hospital, Central South University
来源：
World Journal of Gastrointestinal Oncology | 2021年 / 11期
基金：
中国国家自然科学基金;
关键词：
D O I：
暂无
中图分类号：
R735.9 [胰腺肿瘤];
学科分类号：
100214 ;
摘要：
Pancreatic cancer is a highly lethal malignancy with low resection and survival rates and is not sensitive to radiotherapy and chemotherapy. Ferroptosis is a novel form of nonapoptotic regulated cell death characterized by the accumulation of lipid peroxides and reactive oxygen species involved in iron metabolism.Ferroptosis has a significant role in the occurrence and development of various tumors. Previous studies have shown that regulating ferroptosis-induced cell death inhibited tumor growth in pancreatic cancer and was synergistic with other antitumor drugs to improve treatment sensitivity. Herein, we discuss the mechanism, inducers, and developments of ferroptosis in pancreatic cancer to provide new strategies for the treatment of the malignancy.
引用
收藏
页码：1668 / 1679
页数：12
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