Extraction of Paeonol from CORTEX MOUTAN Based on Central Composite Design

[Objective]To optimize the test parameters for the extraction of paeonol from CORTEX MOUTAN by distillation method.[Method]With paeonol yield as the index,the water addition amount,soaking time and the volume of distilled solution were taken as the investigated factors.Process parameters were optimized and analyzed by design expert7.05 data processing system.[Result]The optimal extraction condition was as follows:94 ml water addition amount,165 min soaking time,and 300 ml distilled solution.Under this condition,the yield of paeonol reached 16.42 mg /g.[Conclusion]Central composite design(CCD) was simple and predictable and could be used for the optimization of extraction parameters of paeonol from CORTEX MOUTAN.