NF-κB and Its Regulation on the Immune System

NF-κB is a transcription factor of eukaryote,whose family comprises five members in mammals and three indrosophila.Transcription factors of the NF-κB family are activated in response to signals that lead to cellgrowth,differentiation,apoptosis and other events.NF-κB takes part in expression of numerous cytokines andadhesion molecules which are critical elements involved in the regulation of immune responses.In this review,we focus on our current understanding of NF-κB signal pathway and its role in the innate and adaptiveimmune responses in which these transcription factors have a key regulatory function.Furthermore we reviewwhat is currently known about their effects associated with apoptosis.Cellular & Molecular Immunology.2004;1(5):343-350.