STUDY ON PLASMA CONCENTRATION OF DRUGS IN STEADY-STATE FOR INTRAVENOUS INJECTION IN MICHAELIS-MENTEN ELIMINATION KINETICS

被引:0
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作者
丁勇
机构
[1] Nanjing 210029
[2] Nanjing Medical College
[3] PRC
关键词
一阶; STUDY ON PLASMA CONCENTRATION OF DRUGS IN STEADY-STATE FOR INTRAVENOUS INJECTION IN MICHAELIS-MENTEN ELIMINATION KINETICS;
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摘要
The Michaelis-Menten elimination process for intravenous injection can be described as-dC/dt= VC/(K+C). (1)The equations for the maximum, minimum and average plasma concentration of drugswhich obey Eq.(1)in steady-state, C, Cand are derived as follows:C=D/[V(1-e)] , (2)
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页码:438 / 439
页数:2
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