Expression of cyclin-dependent kinase inhibitor genes induces apoptosis in human hepatoma cell line

APOPTOSIS is an active, inherently programmed cell death, which has typical morphologicaland biochemical characteristics. Cell death during embryonic development, shaping of the Tand B lymphocyte and tissue dystrophy related to endocrine is designated a physiological apop-tosis by which cell numbers can be effectively controlled. As a process opposite to cell division,there is a balance between apoptosis and cell proliferation. A tumor will develop once the bal-ance is disturbed and the cell division is more rapid than the cell death. Also, apoptosis is un-der the control of multiple molecular components, while cell division is under the control of thecell cycle engine. The precise control of cell proliferation and differentiation is essential for the