Effect of beta-tricalcium phosphate/poly-l-lactide composites on radial bone defects of rabbit

被引：0
|
作者：
Zhao-Jin Zhu [1 ,2 ]
Hao Shen [2 ]
Yong-Ping Wang [3 ]
Yao Jiang [2 ]
Xian-Long Zhang [2 ]
Guang-Yin Yuan [4 ]
机构：
[1] Medical Board of Graduate School of Suzhou University
[2] Orthopedic Surgery of 6th People-s Hospital affiliated to Shanghai Jiaotong University
[3] Orthopaedic Department,First Hospital of Lanzhou University
[4] Materials Science and Engineering Institute of Light Alloy Precision Forming National Engineering Research Center of Shanghai Jiaotong University
来源：
Asian Pacific Journal of Tropical Medicine | 2013年 / 09期
关键词：
β-TCP/PLLA; Large segment of simulated-bioactive; bone substitute; Bone defect;
D O I：
暂无
中图分类号：
R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Objective:To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial lone defects.Methods:Thirty New Zealand rabbits were divided intoβ-TCP/PLLA group(group A),pure PLLA group(group B)and contrast group(group C)randomly.The rabbits were sacrificed respectively after 4.8.12,24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.Retiults:X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A.The defect region was filled with neonate osseous tissue completely during 12-24 weeks.X-ray score revealed that repair of bone defect results significantly better than group B and group C.Conclusions:Theβ-PCP/PLLA composite is capable of repairing radial lone lone defects.β-TCP/PLLA scaffold is significant because of rapid degradation ability,good histocompatihility and osteogenic action.
引用
收藏
页码：753 / 756
页数：4
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