Effect of beta-tricalcium phosphate/poly-l-lactide composites on radial bone defects of rabbit

被引：0

作者：

Zhao-Jin Zhu ^{[1
,2
]}

Hao Shen ^{[2
]}

Yong-Ping Wang ^{[3
]}

Yao Jiang ^{[2
]}

Xian-Long Zhang ^{[2
]}

Guang-Yin Yuan ^{[4
]}

机构：

[1] Medical Board of Graduate School of Suzhou University

[2] Orthopedic Surgery of 6th People-s Hospital affiliated to Shanghai Jiaotong University

[3] Orthopaedic Department,First Hospital of Lanzhou University

[4] Materials Science and Engineering Institute of Light Alloy Precision Forming National Engineering Research Center of Shanghai Jiaotong University

来源：

Asian Pacific Journal of Tropical Medicine | 2013年 / 09期

关键词：

β-TCP/PLLA; Large segment of simulated-bioactive; bone substitute; Bone defect;

D O I：

暂无

中图分类号：

R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Objective:To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial lone defects.Methods:Thirty New Zealand rabbits were divided intoβ-TCP/PLLA group(group A),pure PLLA group(group B)and contrast group(group C)randomly.The rabbits were sacrificed respectively after 4.8.12,24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups.Retiults:X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A.The defect region was filled with neonate osseous tissue completely during 12-24 weeks.X-ray score revealed that repair of bone defect results significantly better than group B and group C.Conclusions:Theβ-PCP/PLLA composite is capable of repairing radial lone lone defects.β-TCP/PLLA scaffold is significant because of rapid degradation ability,good histocompatihility and osteogenic action.

引用

页码：753 / 756

页数：4

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