Effects of Interferon on Mitomycin C-Induced Sister Chromatid Exchanges and on Ultraviolet Induced Unscheduled DNA Synthesis

被引：0
|
作者：
王肖鹏
蒋左庶
胡以平
程浒君
杨连生
机构：
[1] Shanghai
[2] Department of Biology Second Military Medical College
来源：
Journal of Medical Colleges of PLA | 1986年 / 04期
关键词：
xeroderma pigmentosum; interferfons; sister; chromatid exchange; DNA repair; mutagens;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This article is about the effects of interferon(IFN)on sisterchromatid exchange(SCE)frequencies induced by mitomycin C(MMC)and/or unscheduled DNA synthesis(UDS)induced by ultra-violet light(UV).The result shows that SCE frequencies in peri-pheral lymphocytes from 4 normal individuals and 3 patients withxeroderma pigmentosum(XP)treated with IFN before the additionof MMC were much lower than those of the controls.But after thetreatment of IFN followed by UV irradiation,no difference was fo-und between the UDS levels of the lymphocytes from 2 normal in-dividuals and 2 patients with XP and those from the controls.Thewriters deduce that IFN may have some effect of antimutation
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页码：387 / 391
页数：5
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