Morpholine triflate promoted one-pot,four-component synthesis of dihydropyrano[2,3-c]pyrazoles

被引：3

作者：

Chen-Feng Zhou ^{[1
,2
]}

Jian-Jun Li ^{[1
,2
]}

Wei-Ke Su ^{[1
]}

机构：

[1] National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients,Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology

[2] Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education,College of Pharmaceutical Sciences,Zhejiang University of Technology

来源：

ChineseChemicalLetters | 2016年 / 27卷 / 11期

关键词：

Dihydropyrano[2,3-c]pyrazole; MCRs; Morpholine triflate; Green chemistry; Lewis acid;

D O I：

暂无

中图分类号：

O626.21 [邻二氮杂茂（吡唑）族];

学科分类号：

摘要：

A one-pot,four-component reaction of ethyl acetoacetate,hydrazine hydrate,aldehydes,and malononitrile was discussed using Lewis acid catalyst morpholine triflate(MorT) to afford a series of dihydropyrano[2,3-c]pyrazoles,which were generally catalyzed by organic alkalis.Moderate to excellent yields,no chromatographic purification,and evasion of environmentally hazardous solvents in the reaction process make this protocol very useful for academia and industry.

引用

页码：1686 / 1690

页数：5

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