STUDIES OF ELECTRON SPIN RESONANCE ON BILIRUBIN FREE RADICALS

被引：0
|
作者：
杨正红
王夔
刘湘陶
机构：
[1] Beijingmedical univeraity
[2] Department of Inorganic Chemistry
[3] Beijing 100083
[4] Beijing100083
[5] PRC
[6] Beijing Medical University
[7] National Laboratory of Natural and Biomimetic Drugs
来源：
Science in China,SerB. | 1992年 / Ser.B.1992卷 / 09期
基金：
中国国家自然科学基金;
关键词：
bilirubin; ESR; oxygen free radical;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The nature of ESR signals derived from bilirubin-Ⅸα has been studied by focusing onthe samples treated with free radical generating and inhibiting systems, i.e. X-XOD, Fe/EDTA, SOD, mannitol/ascorbate, CO, KCN, etc. In all the cases, the stable signals comprisethose originated from semiquinone radical （g = 2.0012） and superoxide free radical （g=2.041, g= 2.0040）. The superoxide is shown binding with certain metal ions chelated bybilirubin. The free radical scavengers are able to destroy these radicals. The kinetic curveof the regeneration of bilirubin radicals has been determined and the reaction follows azero order mechanism. It is likely that both the physiological and toxic actions of bilirubinare related to the characters of its free radicals. Bilirubin is discussed as "active oxygensink" in mammalians.
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页码：1093 / 1100
页数：8
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