Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction

被引：2
|
作者：
Wen Hao WANG
机构：
来源：
Chinese Chemical Letters | 2005年 / 05期
关键词：
Peptide nucleic acids (PNA); Ugi four-component condensation reaction (U-4CR); Solid-phase synthesis; Isocyanide;
D O I：
暂无
中图分类号：
O621.25 [];
学科分类号：
摘要：
Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.
引用
收藏
页码：585 / 588
页数：4
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