B cells biology in systemic lupus erythematosus—from bench to bedside

被引：0
|
作者：
ZHAO LiDan [1 ]
YE YanXia [1 ]
ZHANG Xuan [1 ]
机构：
[1] Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
来源：
Science China(Life Sciences) | 2015年 / 11期
关键词：
systemic lupus erythematosus; B cell; pathogenesis; target therapy;
D O I：
暂无
中图分类号：
R593.241 [];
学科分类号：
摘要：
Systemic lupus erythematosus(SLE) is a debilitating autoimmune disease that can involve multi-organs. B cells play a central role in the immunopathogenesis via antibody-dependent and antibody-independent ways. Excessive autoantibodies production, hyperresponsiveness and prolonged survival of autoreactive B cells are characteristics of SLE. In this article, mechanisms of self-tolerance loss of B cells and promising B cell-targeting therapies in lupus are reviewed and discussed.
引用
收藏
页码：1111 / 1125
页数：15
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