Modulation of BmKAS-1 and BmK1-3-2 to sodium channel in rat dorsal root ganglion neurons

被引：0
|
作者：
肖杭
毛霞
石云
谭智勇
赵志奇
吉永华
机构：
[1] 南京医科大学应用毒理研究所!南京210029
[2] 中国科学院上海生理研究所!上海200031
来源：
中华医学杂志(英文版) | 2001年 / 03期
关键词：
膜片箝; BmKAS1; BmK132; 背根神经节; 钠通道;
D O I：
暂无
中图分类号：
R338 [神经生理学];
学科分类号：
0710 ; 071006 ;
摘要：
目的　研究新的蝎毒素纯化多肽BmKAS 1及其前级提取物BmK1 3 2对大鼠背根神经节小直径神经元钠通道电流的作用 ,并探讨两者与其外周镇痛作用间的关系。方法　运用全细胞膜片箝技术观察了BmKAS 1和BmK1 3 2对钠电流的作用。结果　 10 μg/ml的BmK1 3 2可阻断约 50 %的峰钠电流 ,而 1 6 2 μg/ml的BmKAS 1即可达到相同的阻断效果 ,同时BmKAS 1对钠电流的作用呈现出明显的剂量反应关系。结论　BmKAS 1和BmK1 3 2对钠电流均有较强的抑制作用。鉴于钠通道与损伤所致的外周神经元感觉过敏有关 ,这种抑制作用可能是BmKAS 1和BmK1 3 2外周镇痛作用的机制之一
引用
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页码：29 / 32+104
页数：5
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