Human Acyl-CoA:cholesterol Acyltransferase (ACAT) and its Potential as a Target for Pharmaceutical Intervention against Atherosclerosis

被引：3
|
作者：
Catherine CHANG
Ruhong DONG
Akira MIYAZAKI
Naomi SAKASHITASecond Department of Pathology
Jay LIU
Michael GUO
机构：
[1] Japan
[2] New Hampshire 03755 USA
[3] Hanover
[4] Tokyo
[5] Department of Biochemistry Dartmouth Medical School
[6] Showa University School of Medicine
来源：
Acta Biochimica et Biophysica Sinica | 2006年 / 03期
关键词：
acyl-CoA; cholesterol acyltransferase; cholesterol; cholesteryl ester; atherosclerosis;
D O I：
暂无
中图分类号：
R543 [血管疾病];
学科分类号：
1002 ; 100201 ;
摘要：
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl estersfrom cholesterol and long-chain fatty-acyl-coenzyme A.At the single-cell level,ACAT serves as a regulatorof intracellular cholesterol homeostasis.In addition,ACAT supplies cholesteryl esters for lipoproteinassembly in the liver and small intestine.Under pathological conditions,the accumulation of cholesterylesters produced by ACAT in macrophages contributes to foam cell formation,a hallmark of the earlystage of atherosclerosis.Several reviews addressing various aspects of ACAT and ACAT inhibitors areavailable [1-8].This review briefly outlines the current knowledge on the biochemical properties of humanACATs,and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventionsagainst atherosclerosis.
引用
收藏
页码：151 / 156
页数：6
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